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Nutrients 2017, 9(1), 29; doi:10.3390/nu9010029

Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery

Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
Author to whom correspondence should be addressed.
Received: 25 November 2016 / Revised: 27 December 2016 / Accepted: 28 December 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Antioxidants in Health and Disease)
View Full-Text   |   Download PDF [416 KB, uploaded 5 January 2017]   |  


(1) Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide, and surgical resection is the main treatment for HCC. To date, no published study has examined the status of coenzyme Q10 in patients with HCC after surgery. Thus, the purpose of this study was to investigate the correlations between the level of coenzyme Q10, oxidative stress, and inflammation in patients with HCC after surgery; (2) Methods: 71 primary HCC patients were recruited. Levels of coenzyme Q10, vitamin E, oxidative stress (malondialdehyde), antioxidant enzymes activity (superoxidase dismutase, catalase, and glutathione peroxidase), and inflammatory markers (high sensitivity C-reactive protein; tumor necrosis factor-α; and interleukin-6) were measured; (3) Results: Patients with HCC had a significantly lower levels of coenzyme Q10 (p = 0.01) and oxidative stress (p < 0.01), and significantly higher levels of antioxidant enzymes activities and inflammation after surgery (p < 0.05). The level of coenzyme Q10 was significantly positively correlated with antioxidant capacity (vitamin E and glutathione peroxidase activity) and negatively correlated with inflammation markers after surgery; (4) Conclusion: Hepatocarcinogenesis is associated with oxidative stress, and coenzyme Q10 may be considered an antioxidant therapy for patients with HCC, particularly those with higher inflammation after surgery. View Full-Text
Keywords: coenzyme Q10; oxidative stress; inflammation; hepatocellular carcinoma; surgery coenzyme Q10; oxidative stress; inflammation; hepatocellular carcinoma; surgery

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Liu, H.-T.; Cheng, S.-B.; Huang, Y.-C.; Huang, Y.-T.; Lin, P.-T. Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery. Nutrients 2017, 9, 29.

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