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Nutrients 2016, 8(9), 580; doi:10.3390/nu8090580

Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis

1
Department of Nutrition, School of Public Health, University of Sao Paulo, Av. Dr. Arnaldo, 715, São Paulo CEP 01246-904, Brazil
2
Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal s/n, Córdoba 14004, Spain
3
CIBER Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid 28029, Spain
4
Department of Epidemiology, School of Public Health, University of Sao Paulo, Av. Dr. Arnaldo, 715, São Paulo CEP 01246-904, Brazil
*
Author to whom correspondence should be addressed.
Received: 14 July 2016 / Revised: 6 September 2016 / Accepted: 12 September 2016 / Published: 21 September 2016
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Abstract

Whether the content of saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) could differently influence postprandial triglycerides (TG) is unknown. We examined possible differences in the postprandial TG response to fat tolerance tests (FTTs), in which SFA or unsaturated fatty acids were used. Crossover clinical trials investigating the effects of FTTs containing SFA and unsaturated fats on postprandial triglyceridemia in databases from 1994 until 2016 were searched. Of 356 studies, 338 were excluded and 18 were considered. TG net incremental areas under the curve were calculated using time-points or changes from baseline. Pooled effects of standardized mean differences and I2 test were used. Results: In 12 studies, responses to SFA versus PUFA meals, and in 16 studies versus MUFA meals were compared. Over 4 hours, no differences between SFA and unsaturated fats were observed. Over 8 hours a lower response to PUFA (SMD −2.28; 95%CI −4.16, −0.41) and a trend to lower response to MUFA (SMD −0.89, 95%CI −1.82, 0.04) were detected. FTTs shorter than 8 hours may not be sufficient to differentiate postprandial TG after challenges with distinct fatty acids. Clinical significance of different postprandial TG responses on cardiovascular risk in the long-term deserves investigation. View Full-Text
Keywords: Fat tolerance test; postprandial triglycerides; saturated fatty acids; polyunsaturated fatty acids; monounsaturated fatty acids Fat tolerance test; postprandial triglycerides; saturated fatty acids; polyunsaturated fatty acids; monounsaturated fatty acids
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MDPI and ACS Style

Monfort-Pires, M.; Delgado-Lista, J.; Gomez-Delgado, F.; Lopez-Miranda, J.; Perez-Martinez, P.; Ferreira, S.R.G. Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis. Nutrients 2016, 8, 580.

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