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Nutrients 2016, 8(7), 409; doi:10.3390/nu8070409

The Effect of Post-Resistance Exercise Amino Acids on Plasma MCP-1 and CCR2 Expression

1
Institute of Exercise Physiology and Wellness, Educational and Human Sciences, University of Central Florida, 12494 University Blvd, Orlando, FL 32816, USA
2
Department of Health Professions, Hofstra University, Hempstead, NY 11549, USA
3
Department of Kinesiology, Lipscomb University, Nashville, TN 37204, USA
4
Department of Exercise Science and Sport Management, Kennesaw State University, Kennesaw, GA 30144, USA
*
Author to whom correspondence should be addressed.
Received: 25 May 2016 / Revised: 22 June 2016 / Accepted: 29 June 2016 / Published: 2 July 2016
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Abstract

The recruitment and infiltration of classical monocytes into damaged muscle is critical for optimal tissue remodeling. This study examined the effects of an amino acid supplement on classical monocyte recruitment following an acute bout of lower body resistance exercise. Ten resistance-trained men (24.7 ± 3.4 years; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm) ingested supplement (SUPP) or placebo (PL) immediately post-exercise in a randomized, cross-over design. Blood samples were obtained at baseline (BL), immediately (IP), 30-min (30P), 1-h (1H), 2-h (2H), and 5-h (5H) post-exercise to assess plasma concentrations of monocyte chemoattractant protein 1 (MCP-1), myoglobin, cortisol and insulin concentrations; and expressions of C-C chemokine receptor-2 (CCR2), and macrophage-1 antigen (CD11b) on classical monocytes. Magnitude-based inferences were used to provide inferences on the true effects of SUPP compared to PL. Changes in myoglobin, cortisol, and insulin concentrations were similar between treatments. Compared to PL, plasma MCP-1 was “very likely greater” (98.1% likelihood effect) in SUPP at 2H. CCR2 expression was “likely greater” at IP (84.9% likelihood effect), “likely greater” at 1H (87.7% likelihood effect), “very likely greater” at 2H (97.0% likelihood effect), and “likely greater” at 5H (90.1% likelihood effect) in SUPP, compared to PL. Ingestion of SUPP did not influence CD11b expression. Ingestion of an amino acid supplement immediately post-exercise appears to help maintain plasma MCP-1 concentrations and augment CCR2 expression in resistance trained men. View Full-Text
Keywords: inflammation; monocyte chemoattractant protein 1 (MCP-1); C-C chemokine receptor 2 (CCR2); macrophage-1 antigen (cluster of differentiation 11b (CD11b)) inflammation; monocyte chemoattractant protein 1 (MCP-1); C-C chemokine receptor 2 (CCR2); macrophage-1 antigen (cluster of differentiation 11b (CD11b))
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wells, A.J.; Hoffman, J.R.; Jajtner, A.R.; Varanoske, A.N.; Church, D.D.; Gonzalez, A.M.; Townsend, J.R.; Boone, C.H.; Baker, K.M.; Beyer, K.S.; Mangine, G.T.; Oliveira, L.P.; Fukuda, D.H.; Stout, J.R. The Effect of Post-Resistance Exercise Amino Acids on Plasma MCP-1 and CCR2 Expression. Nutrients 2016, 8, 409.

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