Next Article in Journal
Dietary, Nutrient Patterns and Blood Essential Elements in Chinese Children with ADHD
Previous Article in Journal
Maternal Dietary Patterns and Pregnancy Outcome
Article Menu

Export Article

Open AccessArticle
Nutrients 2016, 8(6), 337; doi:10.3390/nu8060337

Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial

1
Department of Children’s and Adolescent Health, Public Health College of Harbin Medical University, Harbin 150081, China
2
Zhejiang Provincial Center For Disease Prevention and Control, Hangzhou 310009, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 19 March 2016 / Revised: 29 May 2016 / Accepted: 31 May 2016 / Published: 7 June 2016
View Full-Text   |   Download PDF [1203 KB, uploaded 7 June 2016]   |  

Abstract

Autism spectrum disorders (ASD) are recognized as a major public health issue. Here, we evaluated the effects of folic acid intervention on methylation cycles and oxidative stress in autistic children enrolled in structured teaching. Sixty-six autistic children enrolled in this open-label trial and participated in three months of structured teaching. Forty-four children were treated with 400 μg folic acid (two times/daily) for a period of three months during their structured teaching (intervention group), while the remaining 22 children were not given any supplement for the duration of the study (control group). The Autism Treatment Evaluation Checklist (ATEC) and Psychoeducational Profile-third edition (PEP-3) were measured at the beginning and end of the treatment period. Folic acid, homocysteine, and glutathione metabolism in plasma were measured before and after treatment in 29 autistic children randomly selected from the intervention group and were compared with 29 age-matched unaffected children (typical developmental group). The results illustrated folic acid intervention improved autism symptoms towards sociability, cognitive verbal/preverbal, receptive language, and affective expression and communication. Furthermore, this treatment also improved the concentrations of folic acid, homocysteine, and normalized glutathione redox metabolism. Folic acid supplementation may have a certain role in the treatment of children with autism. View Full-Text
Keywords: autism; folic acid intervention; structured teaching; homocysteine; glutathione redox status autism; folic acid intervention; structured teaching; homocysteine; glutathione redox status
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sun, C.; Zou, M.; Zhao, D.; Xia, W.; Wu, L. Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial. Nutrients 2016, 8, 337.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top