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Nutrients 2016, 8(5), 310; doi:10.3390/nu8050310

The Possible Role of Flavonoids in the Prevention of Diabetic Complications

1
Experimental Models in Clinical Pathology, INRCA-IRCCS National Institute, Ancona I-60127, Italy
2
Scientific Direction, INRCA-IRCCS National Institute, Ancona I-60127, Italy
3
Department of Cardiovascular and Metabolic Diseases, IRCCS Multimedica, Sesto San Giovanni I-20099, Italy
4
Insititut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Rosselló, 149-153, 08036 Barcelona, Spain
5
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona 08036, Spain
*
Author to whom correspondence should be addressed.
Received: 15 March 2016 / Revised: 11 May 2016 / Accepted: 16 May 2016 / Published: 20 May 2016
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Abstract

Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications. View Full-Text
Keywords: type 2 diabetes mellitus; diabetic complications; flavonoids type 2 diabetes mellitus; diabetic complications; flavonoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Testa, R.; Bonfigli, A.R.; Genovese, S.; De Nigris, V.; Ceriello, A. The Possible Role of Flavonoids in the Prevention of Diabetic Complications. Nutrients 2016, 8, 310.

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