Next Article in Journal / Special Issue
Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans
Previous Article in Journal
Algorithms to Improve the Prediction of Postprandial Insulinaemia in Response to Common Foods
Previous Article in Special Issue
Tomato Sauce Enriched with Olive Oil Exerts Greater Effects on Cardiovascular Disease Risk Factors than Raw Tomato and Tomato Sauce: A Randomized Trial
Article Menu

Export Article

Open AccessReview
Nutrients 2016, 8(4), 211; doi:10.3390/nu8040211

Flavonoids in Inflammatory Bowel Disease: A Review

CIBER-EHD, Department of Pharmacology, ibs.GRANADA, Centre for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n 18016-Armilla, Granada, Spain
*
Author to whom correspondence should be addressed.
Received: 1 March 2016 / Revised: 19 March 2016 / Accepted: 30 March 2016 / Published: 9 April 2016
(This article belongs to the Special Issue Flavonoids, Inflammation and Immune System)
View Full-Text   |   Download PDF [3209 KB, uploaded 9 April 2016]   |  

Abstract

Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine that compromises the patients’ life quality and requires sustained pharmacological and surgical treatments. Since their etiology is not completely understood, non-fully-efficient drugs have been developed and those that have shown effectiveness are not devoid of quite important adverse effects that impair their long-term use. In this regard, a growing body of evidence confirms the health benefits of flavonoids. Flavonoids are compounds with low molecular weight that are widely distributed throughout the vegetable kingdom, including in edible plants. They may be of great utility in conditions of acute or chronic intestinal inflammation through different mechanisms including protection against oxidative stress, and preservation of epithelial barrier function and immunomodulatory properties in the gut. In this review we have revised the main flavonoid classes that have been assessed in different experimental models of colitis as well as the proposed mechanisms that support their beneficial effects. View Full-Text
Keywords: inflammatory bowel disease; flavonoids; oxidative stress; eicosanoids; barrier function; immunomodulatory properties inflammatory bowel disease; flavonoids; oxidative stress; eicosanoids; barrier function; immunomodulatory properties
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Vezza, T.; Rodríguez-Nogales, A.; Algieri, F.; Utrilla, M.P.; Rodriguez-Cabezas, M.E.; Galvez, J. Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients 2016, 8, 211.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top