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Nutrients 2016, 8(4), 199; doi:10.3390/nu8040199

Ginseng Berry Extract Attenuates Dextran Sodium Sulfate-Induced Acute and Chronic Colitis

Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China
R & D Unit, AmorePacific Corporation, 1920 Yonggudae-ro, Giheung-gu, Yongin-si, Gyeonggi-do 17074, Korea
Department of Biological Sciences, Inha University, Incheon 22212, Korea
Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Nagasaki 55001, Japan
Department of Immunology and Infectious Diseases, The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA
Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
Author to whom correspondence should be addressed.
Received: 6 January 2016 / Revised: 25 March 2016 / Accepted: 29 March 2016 / Published: 5 April 2016
View Full-Text   |   Download PDF [1837 KB, uploaded 5 April 2016]   |  


This study investigates the in vivo functions of ginseng berry extract (GB) as a therapy for dextran sodium sulfate (DSS)-induced colitis. C57BL/6 mice were given drinking water containing DSS (3%) for eight days to induce acute colitis. At the same time, the mice received an oral dose of GB (50 mg/kg) once daily. The GB-treated mice were less susceptible to the development of acute colitis than were control mice treated with saline, as determined by weight loss, disease activity, and colon histology. The administration of GB to DSS-treated mice also reduced the numbers and inhibited the activation of colon-infiltrating T cells, neutrophils, intestinal CD103CD11c+ dendritic cells (cDCs), and macrophages. In addition, GB treatment promoted the migration of CD103+CD11c+ cDCs and expansion of Foxp3+ regulatory T cells in the colons of DSS-treated mice. Similarly, in the DSS-induced chronic colitis model, GB treatment improved the macroscopic and histological appearance of the colon wall when compared to untreated control mice, as indicated by longer colon length and lower histological scores. This is the first report to show that oral administration of GB suppresses immune activation and protects against experimentally induced colitis. View Full-Text
Keywords: ginseng berry extract; mouse colitis; intestinal dendritic cell; intestinal macrophage ginseng berry extract; mouse colitis; intestinal dendritic cell; intestinal macrophage

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, W.; Xu, L.; Cho, S.-Y.; Min, K.-J.; Oda, T.; Zhang, L.; Yu, Q.; Jin, J.-O. Ginseng Berry Extract Attenuates Dextran Sodium Sulfate-Induced Acute and Chronic Colitis. Nutrients 2016, 8, 199.

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