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Nutrients 2016, 8(4), 193; doi:10.3390/nu8040193

Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats

1
UMR 866 Dynamique Musculaire et Métabolisme, Institut National de la Recherche Agronomique (INRA), Université de Montpellier, F-34060 Montpellier, France
2
Faculté des Sciences de la Nature et de la Vie, Département de Biologie Animale, Laboratoire de Biologie et Environnement, Université Constantine 1, 25000 Constantine, Algeria
3
Unité de recherche (VARENBIOMOL), Département de Chimie, Faculté des Sciences Exactes, Université Constantine 1, 25000 Constantine, Algeria
Permanent address: Laboratoire de Biologie et Environnement, Faculté des Sciences de la Nature et de la Vie, Département de Biologie Animale, Université Constantine 1, 25000 Constantine, Algeria
*
Author to whom correspondence should be addressed.
Received: 17 December 2015 / Revised: 13 March 2016 / Accepted: 21 March 2016 / Published: 1 April 2016
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Abstract

Oxidative stress is a major cause of drug-induced hepatic diseases and several studies have demonstrated that diet supplementation with plants rich in antioxidant compounds provides a variety of health benefits in these circumstances. Genista quadriflora Munby (Gq) and Teucrium polium geyrii Maire (Tp) are known to possess antioxidant and numerous biological properties and these endemic plants are often used for dietary or medicinal applications. Herein, we evaluated the beneficial effect of rich-polyphenol fractions of Gq and Tp to prevent Acetaminophen-induced liver injury and investigated the mechanisms involved in this protective action. Rats were orally administered polyphenolic extracts from Gq or Tp (300 mg/kg) or N-acetylcysteine (NAC: 200 mg/kg) once daily for ten days prior to the single oral administration of Acetaminophen (APAP: 1 g/kg). The results show that preventive administration of polyphenolic extracts from Gq or Tp exerts a hepatoprotective influence during APAP treatment by improving transaminases leakage and liver histology and stimulating antioxidant defenses. Besides, suppression of liver CYP2E1, GSTpi and TNF-α mRNA levels, with enhancement of mitochondrial bioenergetics may contribute to the observed hepatoprotection induced by Gq and Tp extracts. The effect of Tp extract is significantly higher (1.5–2 fold) than that of Gq extract and NAC regarding the enhancement of mitochondrial functionality. Overall, this study brings the first evidence that pretreatment with these natural extracts display in vivo protective activity against APAP hepatotoxicity through improving mitochondrial bioenergetics, oxidant status, phase I and II enzymes expression and inflammatory processes probably by virtue of their high total polyphenols content. View Full-Text
Keywords: acetaminophen; hepatotoxicity; Genista quadriflora Munby; Teucrium polium geyrii Maire; polyphenols; mitochondria; oxidative stress acetaminophen; hepatotoxicity; Genista quadriflora Munby; Teucrium polium geyrii Maire; polyphenols; mitochondria; oxidative stress
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Baali, N.; Belloum, Z.; Baali, S.; Chabi, B.; Pessemesse, L.; Fouret, G.; Ameddah, S.; Benayache, F.; Benayache, S.; Feillet-Coudray, C.; Cabello, G.; Wrutniak-Cabello, C. Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats. Nutrients 2016, 8, 193.

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