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Nutrients 2016, 8(2), 104; doi:10.3390/nu8020104

Cysteic Acid in Dietary Keratin is Metabolized to Glutathione and Liver Taurine in a Rat Model of Human Digestion

1
School of Food and Nutrition, Massey University, Palmerston North 4442, New Zealand
2
Riddet Innovation, Massey University, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
Received: 12 January 2016 / Revised: 5 February 2016 / Accepted: 6 February 2016 / Published: 19 February 2016
View Full-Text   |   Download PDF [212 KB, uploaded 19 February 2016]

Abstract

Poultry feathers, consisting largely of keratin, are a low-value product of the poultry industry. The safety and digestibility of a dietary protein produced from keratin (KER) was compared to a cysteine-supplemented casein-based diet in a growing rat model for four weeks. KER proved to be an effective substitute for casein at 50% of the total dietary protein, with no changes in the rats’ food intake, weight gain, organ weight, bone mineral density, white blood cell counts, liver glutathione, or blood glutathione. Inclusion of KER in the diet reduced total protein digestibility from 94% to 86% but significantly increased total dietary cysteine uptake and subsequent liver taurine levels. The KER diet also significantly increased caecum weight and significantly decreased fat digestibility, resulting in a lower proportion of body fat, and induced a significant increase in blood haemoglobin. KER is therefore a safe and suitable protein substitute for casein, and the cysteic acid in keratin is metabolised to maintain normal liver and blood glutathione levels. View Full-Text
Keywords: cysteine; keratin; rat model; glutathione cysteine; keratin; rat model; glutathione
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wolber, F.M.; McGrath, M.; Jackson, F.; Wylie, K.; Broomfield, A. Cysteic Acid in Dietary Keratin is Metabolized to Glutathione and Liver Taurine in a Rat Model of Human Digestion. Nutrients 2016, 8, 104.

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