Next Article in Journal
Validation of Folate-Enriched Eggs as a Functional Food for Improving Folate Intake in Consumers
Next Article in Special Issue
Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)
Previous Article in Journal
Comparison of Site-Specific Bone Mineral Densities between Endurance Runners and Sprinters in Adolescent Women
Previous Article in Special Issue
A Prospective Study of Different Types of Dietary Fiber and Risk of Cardiovascular Disease: Tehran Lipid and Glucose Study
Article Menu

Export Article

Open AccessFeature PaperArticle
Nutrients 2016, 8(12), 779; doi:10.3390/nu8120779

The Interaction between Dietary Fiber and Fat and Risk of Colorectal Cancer in the Women’s Health Initiative

1
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
2
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98105, USA
3
Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
4
Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
5
Department of Epidemiology, University of Iowa, Iowa City, IA 52242, USA
6
Department of Nutritional Sciences, University of Arizona Cancer Center, Tucson, AZ 85724, USA
7
Department of Oncology and Pathology, Wayne State University, Detroit, MI 48201, USA
8
Program in Integrative Nutrition and Complex Diseases, Texas A&M University, College Station, TX 77843, USA
*
Author to whom correspondence should be addressed.
Received: 1 November 2016 / Revised: 22 November 2016 / Accepted: 25 November 2016 / Published: 30 November 2016
(This article belongs to the Special Issue Dietary Fibers and Human Health)
View Full-Text   |   Download PDF [266 KB, uploaded 30 November 2016]

Abstract

Combined intakes of specific dietary fiber and fat subtypes protect against colon cancer in animal models. We evaluated associations between self-reported individual and combinations of fiber (insoluble, soluble, and pectins, specifically) and fat (omega-6, omega-3, and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), specifically) and colorectal cancer (CRC) risk in the Women’s Health Initiative prospective cohort (n = 134,017). During a mean 11.7 years (1993–2010), 1952 incident CRC cases were identified. Cox regression models computed multivariate adjusted hazard ratios to estimate the association between dietary factors and CRC risk. Assessing fiber and fat individually, there was a modest trend for lower CRC risk with increasing intakes of total and insoluble fiber (p-trend 0.09 and 0.08). An interaction (p = 0.01) was observed between soluble fiber and DHA + EPA, with protective effects of DHA + EPA with lower intakes of soluble fiber and an attenuation at higher intakes, however this association was no longer significant after correction for multiple testing. These results suggest a modest protective effect of higher fiber intake on CRC risk, but not in combination with dietary fat subtypes. Given the robust results in preclinical models and mixed results in observational studies, controlled dietary interventions with standardized intakes are needed to better understand the interaction of specific fat and fiber subtypes on colon biology and ultimately CRC susceptibility in humans. View Full-Text
Keywords: butyrate; colorectal cancer; DHA; EPA; fat; fiber; omega-3; pectin butyrate; colorectal cancer; DHA; EPA; fat; fiber; omega-3; pectin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Navarro, S.L.; Neuhouser, M.L.; Cheng, T.-Y.D.; Tinker, L.F.; Shikany, J.M.; Snetselaar, L.; Martinez, J.A.; Kato, I.; Beresford, S.A.A.; Chapkin, R.S.; Lampe, J.W. The Interaction between Dietary Fiber and Fat and Risk of Colorectal Cancer in the Women’s Health Initiative. Nutrients 2016, 8, 779.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top