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Nutrients 2016, 8(11), 734; doi:10.3390/nu8110734

Beneficial Effects of Pterocarpan-High Soybean Leaf Extract on Metabolic Syndrome in Overweight and Obese Korean Subjects: Randomized Controlled Trial

1
Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea
2
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 702-701, Korea
3
Industrial Bio-Materials Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea
4
Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Korea
5
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
6
Insect Biotech Co., Ltd., Daejeon 305-811, Korea
*
Author to whom correspondence should be addressed.
Received: 11 August 2016 / Revised: 3 November 2016 / Accepted: 16 November 2016 / Published: 18 November 2016
(This article belongs to the Special Issue Health Benefits of Soybean and other Grain Legumes)
View Full-Text   |   Download PDF [499 KB, uploaded 18 November 2016]   |  

Abstract

Pterocarpans are known to have antifungal and anti-inflammatory properties. However, little is known about the changes in transcriptional profiles in response to a pterocarpan-high soybean leaf extract (PT). Therefore, this study investigated the effects of PT on blood glucose and lipid levels, as well as on the inflammation-related gene expression based on a peripheral blood mononuclear cells (PBMCs) mRNA sequencing analysis in Korean overweight and obese subjects with mild metabolic syndrome. The participants were randomly assigned to two groups and were administered either placebo (starch, 3 g/day) or PT (2 g/day) for 12 weeks. The PT intervention did not change body weight, body fat percentage and body mass index (BMI). However, PT significantly decreased the glycosylated hemoglobin (HbA1c), plasma glucose, free fatty acid, total cholesterol, and non-HDL cholesterol levels after 12 weeks. Furthermore, PT supplementation significantly lowered the homeostatic index of insulin resistance, as well as the plasma levels of inflammatory markers. Finally, the mRNA sequencing analysis revealed that PT downregulated genes related to immune responses. PT supplementation is beneficial for the improvement of metabolic syndrome by altering the fasting blood and plasma glucose, HbA1c, plasma lipid levels and inflammation-related gene expression in PBMCs. View Full-Text
Keywords: inflammation; metabolic syndrome; mRNA sequencing; soybean leaf; PBMCs inflammation; metabolic syndrome; mRNA sequencing; soybean leaf; PBMCs
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Ryu, R.; Jeong, T.-S.; Kim, Y.J.; Choi, J.-Y.; Cho, S.-J.; Kwon, E.-Y.; Jung, U.J.; Ji, H.-S.; Shin, D.-H.; Choi, M.-S. Beneficial Effects of Pterocarpan-High Soybean Leaf Extract on Metabolic Syndrome in Overweight and Obese Korean Subjects: Randomized Controlled Trial. Nutrients 2016, 8, 734.

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