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Nutrients 2016, 8(1), 59; doi:10.3390/nu8010059

Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice

1
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 151-742, Korea
2
College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, Korea
3
Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Korea
4
Bio-MAX Institute, Seoul National University, Seoul 151-742, Korea
5
Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Korea
*
Author to whom correspondence should be addressed.
Received: 16 November 2015 / Revised: 6 January 2016 / Accepted: 15 January 2016 / Published: 21 January 2016
(This article belongs to the Special Issue Fatty Acids in Obesity and Type 2 Diabetes)
View Full-Text   |   Download PDF [1924 KB, uploaded 21 January 2016]   |  

Abstract

Korean pine nut oil (PNO) has been reported to influence weight gain and lipid metabolism. We examined whether PNO replacement in a high-fat diet (HFD) can ameliorate HFD-induced hepatic steatosis. Five-week-old male C57BL mice were fed control diets containing 10% of the energy from fat from PNO or soybean oil (SBO) (PC, SC) or HFDs with 45% of the energy from fat, with 10% from PNO or SBO and 35% from lard (PHFD, SHFD), for 12 weeks. Body weight gain and amount of white adipose tissue were lower in PHFD (10% and 18% lower, respectively) compared with SHFD. Hepatic triacylglycerol (TG) level was significantly lower in PHFD than the SHFD (26% lower). PNO consumption upregulated hepatic ACADL mRNA levels. The hepatic PPARG mRNA level was lower in the PC than in the SC. Expression of the sirtuin (SIRT) 3 protein in white adipose tissue was down-regulated in the SHFD and restored in the PHFD to the level in the lean control mice. SIRT 3 was reported to be upregulated under conditions of caloric restriction (CR) and plays a role in regulating mitochondrial function. PNO consumption resulted in lower body fat and hepatic TG accumulation in HFD-induced obesity, which seemed to be associated with the CR-mimetic response. View Full-Text
Keywords: pine nut oil; high-fat diet; obesity; hepatic steatosis; SIRT3 pine nut oil; high-fat diet; obesity; hepatic steatosis; SIRT3
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Park, S.; Shin, S.; Lim, Y.; Shin, J.H.; Seong, J.K.; Han, S.N. Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice. Nutrients 2016, 8, 59.

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