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Nutrients 2016, 8(1), 16; doi:10.3390/nu8010016

Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions

Departments of Food, Nutrition and Health, the University of British Columbia, Vancouver, BC V6T-1Z4, Canada
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Received: 8 October 2015 / Revised: 21 November 2015 / Accepted: 9 December 2015 / Published: 25 December 2015
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Abstract

Chlorogenic acids (CGAs) are esters formed between caffeic and quinic acids, and represent an abundant group of plant polyphenols present in the human diet. CGAs have different subgroups that include caffeoylquinic, p-coumaroylquinic, and feruloyquinic acids. Results of epidemiological studies suggest that the consumption of beverages such as coffee, tea, wine, different herbal infusions, and also some fruit juices is linked to reduced risks of developing different chronic diseases. These beverages contain CGAs present in different concentrations and isomeric mixtures. The underlying mechanism(s) for specific health benefits attributed to CGAs involves mitigating oxidative stress, and hence the related adverse effects associated with an unbalanced intracellular redox state. There is also evidence to show that CGAs exhibit anti-inflammatory activities by modulating a number of important metabolic pathways. This review will focus on three specific aspects of the relevance of CGAs in coffee beverages; namely: (1) the relative composition of different CGA isomers present in coffee beverages; (2) analysis of in vitro and in vivo evidence that CGAs and individual isomers can mitigate oxidative and inflammatory stresses; and (3) description of the molecular mechanisms that have a key role in the cell signaling activity that underlines important functions. View Full-Text
Keywords: chlorogenic acid isomers; coffee; antioxidant activity; oxidative stress; anti-inflammation; inflammatory stress chlorogenic acid isomers; coffee; antioxidant activity; oxidative stress; anti-inflammation; inflammatory stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liang, N.; Kitts, D.D. Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions. Nutrients 2016, 8, 16.

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