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Nutrients 2015, 7(9), 7332-7357; doi:10.3390/nu7095341

Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer’s Disease: Impacts on Cognitive Decline

Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Vanderbilt University, 2213 Garland Ave., Nashville, TN 37232, USA
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Received: 18 April 2015 / Revised: 9 July 2015 / Accepted: 21 August 2015 / Published: 1 September 2015
(This article belongs to the Special Issue Nutrition in Cognitive Function)
View Full-Text   |   Download PDF [361 KB, uploaded 1 September 2015]   |  

Abstract

In the past few decades, the prevalence of obesity and type 2 diabetes mellitus (T2DM), as well as older individuals at risk for Alzheimer’s disease (AD), has increased. While the consumption of diets high in fat (total and saturated) have been linked to increased risk of AD, diets rich in antioxidants, polyunsaturated fats, and omega-3 fatty acids are associated with decreased risk. Additionally, AD patients are at increased risk for developing T2DM. Recent research suggests that there are stronger similarities between AD and T2DM than have previously been considered. Here we review the neurocognitive and inflammatory effects of high-fat diet consumption, its relationship to AD, and the treatment potential of dietary interventions that may decrease risk of cognitive decline and other associated neuropathological changes, such as insulin resistance, oxidative stress, and chronic inflammatory processes. View Full-Text
Keywords: Alzheimer’s disease; type 2 diabetes mellitus; high fat diets; obesity; insulin resistance; inflammation; diet reversal; animal models; humans; cognition Alzheimer’s disease; type 2 diabetes mellitus; high fat diets; obesity; insulin resistance; inflammation; diet reversal; animal models; humans; cognition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Walker, J.M.; Harrison, F.E. Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer’s Disease: Impacts on Cognitive Decline. Nutrients 2015, 7, 7332-7357.

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