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Nutrients 2015, 7(9), 7231-7241; doi:10.3390/nu7095337

High Fat Diet Exposure during Fetal Life Enhances Plasma and Hepatic Omega-6 Fatty Acid Profiles in Fetal Wistar Rats

1
Diabetes Discovery Platform, South African Medical Research Council, P.O. Box 19070, Tygerberg, Cape Town 7505, South Africa
2
Department of Chemistry and Biochemistry, University of San Pablo-CEU, Ctra. Boadilla del Monte km 5.3, Madrid 28668, Spain
*
Author to whom correspondence should be addressed.
Received: 24 March 2015 / Revised: 24 June 2015 / Accepted: 30 June 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
View Full-Text   |   Download PDF [167 KB, uploaded 28 August 2015]   |  

Abstract

Pregnant rats were fed a high fat diet (HFD) for the first (HF1), second (HF2), third (HF3) or all three weeks (HFG) of gestation. Maintenance on a HFD during specific periods of gestation was hypothesized to alter fetal glycemia, insulinemia, induce insulin resistance; and alter fetal plasma and hepatic fatty acid (FA) profiles. At day 20 of gestation, fetal plasma and hepatic FA profiles were determined by gas chromatography; body weight, fasting glycemia, insulinemia and the Homeostasis Model Assessment (HOMA-insulin resistance) were also determined. HF3 fetuses were heaviest concomitant with elevated glycemia and insulin resistance (p < 0.05). HFG fetuses had elevated plasma linoleic (18:2 n-6) and arachidonic (20:4 n-6) acid proportions (p < 0.05). In the liver, HF3 fetuses displayed elevated linoleic, eicosatrienoic (20:3 n-6) and arachidonic acid proportions (p < 0.05). HFG fetuses had reduced hepatic docosatrienoic acid (22:5 n-3) proportions (p < 0.05). High fat maintenance during the final week of fetal life enhances hepatic omega-6 FA profiles in fetuses concomitant with hyperglycemia and insulin resistance thereby presenting a metabolically compromised phenotype. View Full-Text
Keywords: fatty acid analysis; fetal programming; metabolic disease fatty acid analysis; fetal programming; metabolic disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cerf, M.E.; Louw, J.; Herrera, E. High Fat Diet Exposure during Fetal Life Enhances Plasma and Hepatic Omega-6 Fatty Acid Profiles in Fetal Wistar Rats. Nutrients 2015, 7, 7231-7241.

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