Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation
Abstract
:1. Introduction
2. Experimental Section
2.1. Subjects
2.2. Clinical Evaluation
2.3. Parenteral Nutrition
2.4. Sampling and Biochemical Analysis
2.5. Antioxidant Biomarker Analysis
2.6. Antioxidant Defense Enzymes
2.7. Non-Enzymatic Antioxidant Exogenous Compounds
2.8. Statistical Analysis
3. Results
Clinical Parameters | Soybean | FO | p |
---|---|---|---|
Mean Age (months) | 79 ± 56 (28–131) | 94 ± 40 (56–131) | 0.67 |
Sex (male/female) | 4/3 | 3/4 | 1.00 |
Diagnostic: | 0.08 | ||
Acute Leukemia | 6 | 2 | |
Bone marrow aplasia | 0 | 1 | |
Wiskot Aldrich | 0 | 1 | |
Solid tumors | 1 | 3 | |
Type of HSCT | |||
Autologous | 1 | 3 | 0.39 |
Allogenic | 6 | 4 | 0.56 |
Complications: | |||
Mucositis | 7 | 7 | 0.39 |
GVHD | 4 | 2 | 0.43 |
VOD | 1 | 1 | 1 |
Mortality | 1 | 1 | 1 |
Total days of PN | 16.7 ± 7.36 (10.1–23.8) | 16.85 ± 5.52(11.7–22.2) | 0.97 |
Days of PN alone | 12.71 ± 8.42 (6.9–20.5) | 15.28 ± 6.01(9.7–20.8) | 0.52 |
Antioxidant Status
Antioxidants | Lipid Emulsions | Baseline | p | Day 10 | p |
---|---|---|---|---|---|
Vitamin A (mg/L) | Soybean | 0.25 ± 0.11 | 0.25 | 0.24 ± 0.05 | 0.89 |
FO | 0.19 ± 0.06 | 0.25 ± 0.12 | |||
α-tocopherol (mg/L) | Soybean | 5.75 ± 1.04 | 0.27 | 6.62 ± 1.34 | 0.03 * |
FO | 6.39 ± 0.94 | 8.29 ± 1.10 | |||
β-carotene (μg/L) | Soybean a | 503.15(2482.12) | 0.39 | 282.86(596.13) | 0.75 |
FO a | 767.94(1344.77) | 212.17(206.61) | |||
Q9 (μg/L) | Soybean | 10.99 ± 2.56 | 0.39 | 12.55 ± 3.57 | 0.64 |
FO | 9.89 ± 1.91 | 13.96 ± 6.47 | |||
Q10 (μg/L) | Soybean | 146.23 ± 92.70 | 0.51 | 142.25 ± 64.23 | 0.64 |
FO | 120.20 ± 33.82 | 170.14 ± 141.92 | |||
SOD (U/mg Hb) | Soybean | 1.86 ± 0.93 | 0.69 | 1.60 ± 0.91 | 0.34 |
FO | 2.03 ± 0.56 | 2.03 ± 0.64 | |||
GR (μmol/min·g−1 Hb) | Soybean | 2.36 ± 0.80 | 0.07 | 2.68 ±0.91 | 0.49 |
FO | 3.11 ± 0.52 | 2.41 ± 0.39 | |||
CAT (nmol/seg·g−1 Hb) | Soybean | 5.71 ± 1.10 | 0.67 | 7.45 ± 1.60 | 0.09 |
FO | 5.98 ± 1.17 | 5.95 ± 1.30 | |||
GPOX (μmol/g Hb) | Soybean | 11.94 ± 6.13 | 0.74 | 10.13 ± 4.61 | 0.23 |
FO | 12.90 ± 4.38 | 13.26 ± 4.27 | |||
GPOX (μU/g Hb) | Soybean | 10.36 ± 5.32 | 0.74 | 8.79 ± 4.00 | 0.23 |
FO | 11.20 ± 3.80 | 11.51 ± 3.71 |
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of interest
References
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Baena-Gómez, M.A.; Aguilar, M.J.D.L.T.; Mesa, M.D.; Navero, J.L.P.; Gil-Campos, M. Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation. Nutrients 2015, 7, 7242-7255. https://doi.org/10.3390/nu7095335
Baena-Gómez MA, Aguilar MJDLT, Mesa MD, Navero JLP, Gil-Campos M. Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation. Nutrients. 2015; 7(9):7242-7255. https://doi.org/10.3390/nu7095335
Chicago/Turabian StyleBaena-Gómez, María Auxiliadora, María José De La Torre Aguilar, María Dolores Mesa, Juan Luis Pérez Navero, and Mercedes Gil-Campos. 2015. "Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation" Nutrients 7, no. 9: 7242-7255. https://doi.org/10.3390/nu7095335