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Nutrients 2015, 7(8), 6213-6223; doi:10.3390/nu7085279

The Fate of Fat: Pre-Exposure Fat Losses during Nasogastric Tube Feeding in Preterm Newborns

Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Translational Research Center for Gastrointestinal Diseases, KU Leuven, 3000 Leuven, Belgium
Neuro-gastroenterology and Motility, Gastroenterology, 3000 Leuven, Belgium
Neurosciences, Exp ORL, KU Leuven, Herestraat 49, O & N 2, PO Box 79, 3000 Leuven, Belgium
Author to whom correspondence should be addressed.
Received: 4 June 2015 / Revised: 15 July 2015 / Accepted: 23 July 2015 / Published: 29 July 2015
View Full-Text   |   Download PDF [220 KB, uploaded 29 July 2015]   |  


Deficient nutritional support and subsequent postnatal growth failure are major covariates of short- and long-term outcome in preterm neonates. Despite its relevance, extrauterine growth restriction (EUGR) is still prevalent, occurring in an important portion of extremely preterm infants. Lipids provide infants with most of their energy needs, but also cover specific supplies critical to growth, development and health. The use of human milk in preterm neonates results in practices, such as milk storage, pasteurization and administration by an infusion system. All of these pre-exposure manipulations significantly affect the final extent of lipid deposition in the intestinal track available for absorption, but the impact of tube feeding is the most significant. Strategies to shift earlier to oral feeding are available, while adaptations of the infusion systems (inversion, variable flow) have only more recently been shown to be effective in “in vitro”, but not yet in “in vivo” settings. Pre-exposure-related issues for drugs and nutritional compounds show similarities. Therefore, we suggest that the available practices for “in vitro” drug evaluations should also be considered in feeding strategies to further reduce pre-exposure losses as a strategy to improve the nutritional status and outcome of preterm neonates. View Full-Text
Keywords: preterm; nutritional support; lipids; nasogastric tube feeding; fat delivery; absorption preterm; nutritional support; lipids; nasogastric tube feeding; fat delivery; absorption

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rayyan, M.; Rommel, N.; Allegaert, K. The Fate of Fat: Pre-Exposure Fat Losses during Nasogastric Tube Feeding in Preterm Newborns. Nutrients 2015, 7, 6213-6223.

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