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Nutrients 2015, 7(8), 6179-6194; doi:10.3390/nu7085275

Mamao Pomace Extract Alleviates Hypertension and Oxidative Stress in Nitric Oxide Deficient Rats

1
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
2
Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
3
Department of Physical Therapy, Faculty of Associated Medical Science, Khon Kaen University, Khon Kaen 40002, Thailand
4
Department of Food Technology, Faculty of Technology, Khon Kaen University, Khon Kaen 40002, Thailand
5
Faculty of Allied Health Sciences, Burapha University, Chonburi 20131, Thailand
*
Author to whom correspondence should be addressed.
Received: 1 June 2015 / Revised: 15 July 2015 / Accepted: 15 July 2015 / Published: 28 July 2015
(This article belongs to the Special Issue Natural Products for Human Health)
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Abstract

Reactive oxygen species (ROS)-induced oxidative stress plays a major role in pathogenesis of hypertension. Antidesma thwaitesianum (local name: Mamao) is a tropical plant distributed in the tropical/subtropical areas of the world, including Thailand. Mamao pomace (MP), a by-product generated from Mamao fruits, contains large amounts of antioxidant polyphenolic compounds. The aim of this study was to investigate the antihypertensive and antioxidative effects of MP using hypertensive rats. For this purpose, male Sprague-Dawley rats were given Nω-nitro-l-arginine methyl ester (l-NAME), an inhibitor of endothelial nitric oxide synthase (eNOS), in drinking water (50 mg/kg) for three weeks. MP extract was orally administered daily at doses of 100 and 300 mg/kg. l-NAME administration induced marked increase in blood pressure, peripheral vascular resistance, and oxidative stress. MP treatment significantly prevented the increase in blood pressure, hindlimb blood flow and hindlimb vascular resistance of l-NAME treated hypertensive rats (p < 0.05). The antihypertensive effect of MP treatment was associated with suppression of superoxide production from carotid strips and also with an increase in eNOS protein expression and nitric oxide bioavailability. The present results provide evidence for the antihypertensive effect of MP and suggest that MP might be useful as a dietary supplement against hypertension. View Full-Text
Keywords: Antidesma thwaitesianum; antioxidant; endothelial dysfunction; hypertension; l-NAME; Mamao pomace; nitric oxide; oxidative stress Antidesma thwaitesianum; antioxidant; endothelial dysfunction; hypertension; l-NAME; Mamao pomace; nitric oxide; oxidative stress
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kukongviriyapan, U.; Kukongviriyapan, V.; Pannangpetch, P.; Donpunha, W.; Sripui, J.; Sae-Eaw, A.; Boonla, O. Mamao Pomace Extract Alleviates Hypertension and Oxidative Stress in Nitric Oxide Deficient Rats. Nutrients 2015, 7, 6179-6194.

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