NO-Rich Diet for Lifestyle-Related Diseases
AbstractDecreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero-salivary nitrate-nitrite-NO pathway might serve as a backup system for NO generation by transmitting NO activities in the various molecular forms including NO and protein S-nitrosothiols. Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. This review provides an overview of our current knowledge of NO generation through the entero-salivary pathway and discusses its safety and preventive effects on lifestyle-related diseases. View Full-Text
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Kobayashi, J.; Ohtake, K.; Uchida, H. NO-Rich Diet for Lifestyle-Related Diseases. Nutrients 2015, 7, 4911-4937.
Kobayashi J, Ohtake K, Uchida H. NO-Rich Diet for Lifestyle-Related Diseases. Nutrients. 2015; 7(6):4911-4937.Chicago/Turabian Style
Kobayashi, Jun; Ohtake, Kazuo; Uchida, Hiroyuki. 2015. "NO-Rich Diet for Lifestyle-Related Diseases." Nutrients 7, no. 6: 4911-4937.