Next Article in Journal
Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis
Next Article in Special Issue
Zinc Status of Vegetarians during Pregnancy: A Systematic Review of Observational Studies and Meta-Analysis of Zinc Intake
Previous Article in Journal
Food Choice Architecture: An Intervention in a Secondary School and its Impact on Students’ Plant-based Food Choices
Previous Article in Special Issue
Zinc Status Affects Glucose Homeostasis and Insulin Secretion in Patients with Thalassemia
Article Menu

Export Article

Open AccessReview
Nutrients 2015, 7(6), 4438-4452; doi:10.3390/nu7064438

Crosstalk between Zinc Status and Giardia Infection: A New Approach

1
Departamento de Nutrición y Metabolismo, Coordinación de Nutrición, Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera a La Victoria Km 0.6, Hermosillo, Sonora, CP 83304, Mexico
2
Departamento de Nutrición Pública y Salud, Coordinación de Nutrición, Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera a La Victoria Km 0.6, Hermosillo, Sonora, C.P. 83304, Mexico
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 30 March 2015 / Revised: 6 May 2015 / Accepted: 12 May 2015 / Published: 3 June 2015
(This article belongs to the Special Issue Dietary Zinc and Human Health)
View Full-Text   |   Download PDF [112 KB, uploaded 3 June 2015]

Abstract

Zinc supplementation has been shown to reduce the incidence and prevalence of diarrhea; however, its anti-diarrheal effect remains only partially understood. There is now growing evidence that zinc can have pathogen-specific protective effects. Giardiasis is a common yet neglected cause of acute-chronic diarrheal illness worldwide which causes disturbances in zinc metabolism of infected children, representing a risk factor for zinc deficiency. How zinc metabolism is compromised by Giardia is not well understood; zinc status could be altered by intestinal malabsorption, organ redistribution or host-pathogen competition. The potential metal-binding properties of Giardia suggest unusual ways that the parasite may interact with its host. Zinc supplementation was recently found to reduce the rate of diarrhea caused by Giardia in children and to upregulate humoral immune response in Giardia-infected mice; in vitro and in vivo, zinc-salts enhanced the activity of bacitracin in a zinc-dose-dependent way, and this was not due to zinc toxicity. These findings reflect biological effect of zinc that may impact significantly public health in endemic areas of infection. In this paper, we shall explore one direction of this complex interaction, discussing recent information regarding zinc status and its possible contribution to the outcome of the encounter between the host and Giardia. View Full-Text
Keywords: zinc supplementation; zinc deficiency; Giardia lamblia; giardiasis; parasite infection; micronutrient supplementation zinc supplementation; zinc deficiency; Giardia lamblia; giardiasis; parasite infection; micronutrient supplementation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Astiazarán-García, H.; Iñigo-Figueroa, G.; Quihui-Cota, L.; Anduro-Corona, I. Crosstalk between Zinc Status and Giardia Infection: A New Approach. Nutrients 2015, 7, 4438-4452.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top