Next Article in Journal
Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial
Previous Article in Journal
The Effect of Plant Proteins Derived from Cereals and Legumes on Heme Iron Absorption
Article Menu

Export Article

Open AccessReview
Nutrients 2015, 7(11), 8987-9004; doi:10.3390/nu7115445

Polyphenol Compound as a Transcription Factor Inhibitor

Department of Applied Chemistry, Dongduk Women’s University, Seoul 136-714, Korea
Received: 15 July 2015 / Revised: 12 October 2015 / Accepted: 23 October 2015 / Published: 30 October 2015
View Full-Text   |   Download PDF [7941 KB, uploaded 30 October 2015]   |  

Abstract

A target-based approach has been used to develop novel drugs in many therapeutic fields. In the final stage of intracellular signaling, transcription factor–DNA interactions are central to most biological processes and therefore represent a large and important class of targets for human therapeutics. Thus, we focused on the idea that the disruption of protein dimers and cognate DNA complexes could impair the transcriptional activation and cell transformation regulated by these proteins. Historically, natural products have been regarded as providing the primary leading compounds capable of modulating protein–protein or protein-DNA interactions. Although their mechanism of action is not fully defined, polyphenols including flavonoids were found to act mostly as site-directed small molecule inhibitors on signaling. There are many reports in the literature of screening initiatives suggesting improved drugs that can modulate the transcription factor interactions responsible for disease. In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and β-catenin/T cell factor (Tcf)). View Full-Text
Keywords: transcription factor; c-jun/c-fos (AP-1); c-myc/max; NF-κB; β-catenin/Tcf; polyphenol. transcription factor; c-jun/c-fos (AP-1); c-myc/max; NF-κB; β-catenin/Tcf; polyphenol.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Park, S. Polyphenol Compound as a Transcription Factor Inhibitor. Nutrients 2015, 7, 8987-9004.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top