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Nutrients 2015, 7(11), 8939-8951; doi:10.3390/nu7115442

Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial

Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Mexico City 04530, México
Hospital General de México Dr. Eduardo Liceaga, Mexico City 06726, México
Urgencias Pediatría, Centro Médico ABC, Santa Fe 05300, México
Laboratorio de Biología Molecular, Instituto Nacional de Pediatría, Mexico City 04530, México
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City 04510, México
Nekutli, S.A. de C.V., Zapopan, Jalisco 45070, México
Centro Mexicano de Fomento al Desarrollo, Hidalgo 04212, México
Unidad de Investigación Traslacional & Centro de Análisis de la Evidencia, Hospital General Dr. Manuel Gea González, Mexico City 14080, México
Authors to whom correspondence should be addressed.
Received: 19 August 2015 / Accepted: 20 October 2015 / Published: 29 October 2015
View Full-Text   |   Download PDF [805 KB, uploaded 29 October 2015]   |  


Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin® and Metlos®) was demonstrated. Methods: This study aimed to demonstrate the efficacy as prebiotics of Metlin® and Metlos® in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes. Results: There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin® and Metlos®. Conclusions: Our results support the efficacy of Metlin® and Metlos® as prebiotics in humans, and stand the bases to recommend their consumption. Trial Registration:, NCT 01251783. View Full-Text
Keywords: soluble fiber; infant microbiota; breast milk; immune response soluble fiber; infant microbiota; breast milk; immune response

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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López-Velázquez, G.; Parra-Ortiz, M.; Mora, I.D.-D.; García-Torres, I.; Enríquez-Flores, S.; Alcántara-Ortigoza, M.A.; Angel, A.G.-D.; Velázquez-Aragón, J.; Ortiz-Hernández, R.; Cruz-Rubio, J.M.; Villa-Barragán, P.; Jiménez-Gutiérrez, C.; Gutiérrez-Castrellón, P. Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial. Nutrients 2015, 7, 8939-8951.

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