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Nutrients 2015, 7(10), 8685-8699; doi:10.3390/nu7105420

Consumption of Milk Protein or Whey Protein Results in a Similar Increase in Muscle Protein Synthesis in Middle Aged Men

1
Liggins Institute, University of Auckland, Auckland 1142, New Zealand
2
School of Biological Sciences, University of Auckland, Auckland 1142, New Zealand
3
Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Busan 614-735, Korea
4
Fonterra Research and Development Centre, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
Received: 2 September 2015 / Revised: 23 September 2015 / Accepted: 29 September 2015 / Published: 21 October 2015
(This article belongs to the Special Issue Dietary Protein, Exercise and Muscle Health in an Ageing Population)
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Abstract

The differential ability of various milk protein fractions to stimulate muscle protein synthesis (MPS) has been previously described, with whey protein generally considered to be superior to other fractions. However, the relative ability of a whole milk protein to stimulate MPS has not been compared to whey. Sixteen healthy middle-aged males ingested either 20 g of milk protein (n = 8) or whey protein (n = 8) while undergoing a primed constant infusion of ring 13C6 phenylalanine. Muscle biopsies were obtained 120 min prior to consumption of the protein and 90 and 210 min afterwards. Resting myofibrillar fractional synthetic rates (FSR) were 0.019% ± 0.009% and 0.021% ± 0.018% h−1 in the milk and whey groups respectively. For the first 90 min after protein ingestion the FSR increased (p < 0.001) to 0.057% ± 0.018% and 0.052% ± 0.024% h−1 in the milk and whey groups respectively with no difference between groups (p = 0.810). FSR returned to baseline in both groups between 90 and 210 min after protein ingestion. Despite evidence of increased rate of digestion and leucine availability following the ingestion of whey protein, there was similar activation of MPS in middle-aged men with either 20 g of milk protein or whey protein. View Full-Text
Keywords: fractional synthetic rate; amino acids; stable isotopes; milk protein; whey protein; muscle fractional synthetic rate; amino acids; stable isotopes; milk protein; whey protein; muscle
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mitchell, C.J.; McGregor, R.A.; D’Souza, R.F.; Thorstensen, E.B.; Markworth, J.F.; Fanning, A.C.; Poppitt, S.D.; Cameron-Smith, D. Consumption of Milk Protein or Whey Protein Results in a Similar Increase in Muscle Protein Synthesis in Middle Aged Men. Nutrients 2015, 7, 8685-8699.

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