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Nutrients 2015, 7(1), 625-645; doi:10.3390/nu7010625

Lipid Extract from Hard-Shelled Mussel (Mytilus coruscus) Improves Clinical Conditions of Patients with Rheumatoid Arthritis: A Randomized Controlled Trial

1
Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China
2
Department of Rheumatology, Zhejiang Sir Run Run Shaw Hospital, Hangzhou 310058, China
3
Department of Orthopaedic Surgery, The General Hospital of Chinese People's Army Police Force, Beijing 100039, China
4
College of Life Science, Linyi University, Linyi 276005, China
5
Ningbo College of Health Sciences, Ningbo 315100, China
*
Author to whom correspondence should be addressed.
Received: 21 October 2014 / Accepted: 19 December 2014 / Published: 16 January 2015
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Abstract

Studies have suggested a lipid extract from hard-shelled mussel (Mytilus coruscus) (HMLE) possessed strong anti-inflammatory activity in arthritis model of rats. This study investigated whether HMLE could improve clinical conditions of rheumatoid arthritis patients. Fifty rheumatoid arthritis patients (28–75 years) were randomly assigned to receive HMLE capsules or receive placebo capsules for 6 months. Forty-two subjects and 50 subjects were included in per-protocol and intention-to-treat analysis, respectively. Significant differences in changes on disease activity score (DAS28) and clinical disease activity index (CDAI) after 6-month intervention (p < 0.01) were observed in both analyses with more evident efficacy shown in per-protocol population (∆DAS28 = 0.47; ∆CDAI = 4.17), which favored the benefits of the HMLE group. TNF-α (tumor necrosis factor α), interleukin (IL)-1β and PGE2 (prostaglandin E2) but not IL-6, were significantly decreased in both groups, and the decrements were much larger in the HMLE group for TNF-α and PGE2 after 6 months from baseline (p < 0.05). IL-10 was significantly increased in both groups and the change was much more evident in the HMLE group (p < 0.05). In conclusion, HMLE exhibited benefits for the clinical conditions of rheumatoid patients in relation to improvement in the balance between pro- and anti-inflammatory factors, which indicated its potential to serve as adjunctive treatment for rheumatoid arthritis. (ClinicalTrials.gov NCT02173587). View Full-Text
Keywords: anti-inflammation; clinical conditions; hard-shelled mussel; lipid extract; rheumatoid arthritis anti-inflammation; clinical conditions; hard-shelled mussel; lipid extract; rheumatoid arthritis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fu, Y.; Li, G.; Zhang, X.; Xing, G.; Hu, X.; Yang, L.; Li, D. Lipid Extract from Hard-Shelled Mussel (Mytilus coruscus) Improves Clinical Conditions of Patients with Rheumatoid Arthritis: A Randomized Controlled Trial. Nutrients 2015, 7, 625-645.

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