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Nutrients 2015, 7(1), 321-334; doi:10.3390/nu7010321

Molecular Targets of Naturopathy in Cancer Research: Bridge to Modern Medicine

1
Department of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
2
Interdisciplinary Science & Technology Research Academy Department of Chemistry, Maharashtra Cosmopolitan Education Society's Abeda Inamdar Senior College of Arts, Science and Commerce, Pune 411001, India
3
Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
*
Author to whom correspondence should be addressed.
Received: 13 November 2014 / Accepted: 23 December 2014 / Published: 6 January 2015
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Abstract

The relevance of naturopathy (defined as the practice of medicine for the treatment of human diseases with natural agents) in human cancer is beginning to be appreciated, as documented by renewed interest in nutraceutical research, the natural anticancer agents of dietary origin. Because of their pleiotropic effects and the ability to modulate multiple signaling pathways, which is a good attribute of natural agents, nutraceuticals have frequently been demonstrated to re-sensitize drug-resistant cancers. The effectiveness of nutraceuticals can be further enhanced if the tools for the relative assessment of their molecular targets are readily available. Such information can be critical for determining their most effective uses. Here, we discuss the anticancer potential of nutraceuticals and the associated challenges that have interfered with their translational potential as a naturopathic approach for the management of cancers. In the years to come, an efficient screening and assessment of molecular targets will be the key to make rapid progress in the area of drug design and discovery, especially focusing on evidence-based development of naturopathy for the treatment of human malignancies. View Full-Text
Keywords: cancer; naturopathy; nutraceuticals cancer; naturopathy; nutraceuticals
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ahmad, A.; Ginnebaugh, K.R.; Li, Y.; Padhye, S.B.; Sarkar, F.H. Molecular Targets of Naturopathy in Cancer Research: Bridge to Modern Medicine. Nutrients 2015, 7, 321-334.

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