Next Article in Journal
Fishy Business: Effect of Omega-3 Fatty Acids on Zinc Transporters and Free Zinc Availability in Human Neuronal Cells
Previous Article in Journal
Vitamin E Supplementation in Chemical Colorectal Carcinogenesis: A Two-Edged Knife
Article Menu

Export Article

Open AccessArticle
Nutrients 2014, 6(8), 3230-3244; doi:10.3390/nu6083230

A Significant Inhibitory Effect on Advanced Glycation End Product Formation by Catechin as the Major Metabolite of Lotus Seedpod Oligomeric Procyanidins

1
Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China
2
College of food science and engineering, Wuhan Polytechnic University, Wuhan, Hubei 430070, China
3
College of Food and Biology Science and Technology, Chutian College, Huazhong Agricultural University, Wuhan, Hubei 430070, China
*
Author to whom correspondence should be addressed.
Received: 29 April 2014 / Revised: 16 July 2014 / Accepted: 4 August 2014 / Published: 13 August 2014
View Full-Text   |   Download PDF [273 KB, uploaded 13 August 2014]   |  

Abstract

Several lines of evidence suggested that B-type procyanidin oligomers from lotus seedpod (LSOPC) may effectively modulate the formation of advanced glycation end products (AGEs). In vivo, LSOPC is metabolized by intestinal flora to become various kinds of phenolic compounds that possess potent antioxidant activities. However, few reports of the absorption and metabolism of LSOPC have been revealed. In the present study, rats were orally administered with LSOPC at a dose of 300 mg/kg body weight. The metabolites of LSOPC in urine were elucidated by HPLC-MS/MS analysis 24 h post-administration. Eight major metabolites were significantly increased by the administration of 300 mg/kg of LSOPC (p < 0.01). The anti-glycative activity of LSOPC and its metabolites were investigated. The results showed that LSOPC and catechin had greater anti-glycative activities than other metabolites, which were positively correlated to their carbonyl scavenging activities and antioxidant capacities. View Full-Text
Keywords: advanced glycation end products (AGEs); lotus seedpod oligomeric procyanidins (LSOPC); metabolites; carbonyl; antioxidant advanced glycation end products (AGEs); lotus seedpod oligomeric procyanidins (LSOPC); metabolites; carbonyl; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wu, Q.; Li, S.; Li, X.; Fu, X.; Sui, Y.; Guo, T.; Xie, B.; Sun, Z. A Significant Inhibitory Effect on Advanced Glycation End Product Formation by Catechin as the Major Metabolite of Lotus Seedpod Oligomeric Procyanidins. Nutrients 2014, 6, 3230-3244.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top