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Nutrients 2014, 6(5), 1931-1944; doi:10.3390/nu6051931
Article

Antinociceptive and Anti-Inflammatory Activities of the Sesame Oil and Sesamin

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1 Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil 2 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil
* Author to whom correspondence should be addressed.
Received: 6 January 2014 / Revised: 13 March 2014 / Accepted: 14 April 2014 / Published: 12 May 2014
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Abstract

Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.
Keywords: sesame oil; sesamin; antinociceptive activity; anti-inflammatory activity sesame oil; sesamin; antinociceptive activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Monteiro, É.M.H.; Chibli, L.A.; Yamamoto, C.H.; Pereira, M.C.S.; Vilela, F.M.P.; Rodarte, M.P.; de Oliveira Pinto, M.A.; da Penha Henriques do Amaral, M.; Silvério, M.S.; de Matos Araújo, A.L.S.; da Luz André de Araújo, A.; Del-Vechio-Vieira, G.; de Sousa, O.V. Antinociceptive and Anti-Inflammatory Activities of the Sesame Oil and Sesamin. Nutrients 2014, 6, 1931-1944.

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