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Nutrients 2014, 6(4), 1364-1373; doi:10.3390/nu6041364

l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation

1
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil
2
Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 8 January 2014 / Revised: 28 February 2014 / Accepted: 18 March 2014 / Published: 2 April 2014
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Abstract

Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.
Keywords: BCAA; amino acids; obesity; high-fat diet; energy balance; food intake; energy expenditure; hypothalamus BCAA; amino acids; obesity; high-fat diet; energy balance; food intake; energy expenditure; hypothalamus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zampieri, T.T.; Torres-Leal, F.L.; Campaña, A.B.; Lima, F.B.; Donato, J., Jr. l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation. Nutrients 2014, 6, 1364-1373.

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