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Nutrients 2014, 6(4), 1364-1373; doi:10.3390/nu6041364
Short Communication

l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation

1,†
, 1,2,†
, 1
, 1
 and Jr. 1,*
1 Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil 2 Department of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, Brazil These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 8 January 2014 / Revised: 28 February 2014 / Accepted: 18 March 2014 / Published: 2 April 2014
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Abstract

Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.
Keywords: BCAA; amino acids; obesity; high-fat diet; energy balance; food intake; energy expenditure; hypothalamus BCAA; amino acids; obesity; high-fat diet; energy balance; food intake; energy expenditure; hypothalamus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zampieri, T.T.; Torres-Leal, F.L.; Campaña, A.B.; Lima, F.B.; Donato, J., Jr. l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation. Nutrients 2014, 6, 1364-1373.

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