Nutrients 2014, 6(4), 1364-1373; doi:10.3390/nu6041364
Short Communication

l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation

1,†email, 1,2,†email, 1email, 1email and Jr. 1,* email
Received: 8 January 2014; in revised form: 28 February 2014 / Accepted: 18 March 2014 / Published: 2 April 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation. In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.
Keywords: BCAA; amino acids; obesity; high-fat diet; energy balance; food intake; energy expenditure; hypothalamus
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MDPI and ACS Style

Zampieri, T.T.; Torres-Leal, F.L.; Campaña, A.B.; Lima, F.B.; Donato, J., Jr. l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation. Nutrients 2014, 6, 1364-1373.

AMA Style

Zampieri TT, Torres-Leal FL, Campaña AB, Lima FB, Donato J, Jr. l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation. Nutrients. 2014; 6(4):1364-1373.

Chicago/Turabian Style

Zampieri, Thais T.; Torres-Leal, Francisco L.; Campaña, Amanda B.; Lima, Fabio B.; Donato, Jose, Jr. 2014. "l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation." Nutrients 6, no. 4: 1364-1373.

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