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Nutrients 2014, 6(12), 6095-6109; doi:10.3390/nu6126095

The Role of Dietary Fat throughout the Prostate Cancer Trajectory

Department of Kinesiology, University of Waterloo, 200 University Avenue W., Waterloo, ON N2L 3G1, Canada
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Received: 16 October 2014 / Revised: 5 December 2014 / Accepted: 11 December 2014 / Published: 22 December 2014
(This article belongs to the Special Issue Nutrition and Cancer)
View Full-Text   |   Download PDF [200 KB, uploaded 22 December 2014]

Abstract

Prostate cancer is the second most common cancer diagnosed world-wide; however, patients demonstrate exceptionally high survival rates. Many lifestyle factors, including obesity and diet, are considered risk factors for advanced prostate cancer. Dietary fat is a fundamental contributor to obesity and may be specifically important for prostate cancer patients. Prostate cancer treatment can result in changes in body composition, affecting quality of life for survivors by increasing the risk of co-morbidities, like cardiovascular disease and diabetes. We aim to examine dietary fat throughout the prostate cancer treatment trajectory, including risk, cancer development and survivorship. Focusing on one specific nutrient throughout the prostate cancer trajectory provides a unique perspective of dietary fat in prostate cancer and the mechanisms that may exacerbate prostate cancer risk, progression and recurrence. Through this approach, we noted that high intake of dietary fat, especially, high intake of animal and saturated fats, may be associated with increased prostate cancer risk. In contrast, a low-fat diet, specifically low in saturated fat, may be beneficial for prostate cancer survivors by reducing tumor angiogenesis and cancer recurrence. The insulin-like growth factor (IGF)/Akt signaling pathway appears to be the key pathway moderating dietary fat intake and prostate cancer development and progression. View Full-Text
Keywords: risk; progression; survivorship; IGF signaling; saturated fatty acids; monounsaturated fatty acids; polyunsaturated fatty acids; trans fatty acids risk; progression; survivorship; IGF signaling; saturated fatty acids; monounsaturated fatty acids; polyunsaturated fatty acids; trans fatty acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Di Sebastiano, K.M.; Mourtzakis, M. The Role of Dietary Fat throughout the Prostate Cancer Trajectory. Nutrients 2014, 6, 6095-6109.

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