Next Article in Journal
Vitamin D Status and Related Factors in Newborns in Shanghai, China
Next Article in Special Issue
The Role of Dietary Sugars and De novo Lipogenesis in Non-Alcoholic Fatty Liver Disease
Previous Article in Journal
Supplementation of Adult Rats with Moderate Amounts of β-Carotene Modulates the Redox Status in Plasma without Exerting Pro-Oxidant Effects in the Brain: A Safer Alternative to Food Fortification with Vitamin A?
Previous Article in Special Issue
Does Vitamin C Deficiency Promote Fatty Liver Disease Development?
Article Menu

Export Article

Open AccessReview
Nutrients 2014, 6(12), 5583-5599; doi:10.3390/nu6125583

The Role of Intestinal Bacteria Overgrowth in Obesity-Related Nonalcoholic Fatty Liver Disease

Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Brazil
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 9 September 2014 / Revised: 24 November 2014 / Accepted: 26 November 2014 / Published: 3 December 2014
(This article belongs to the Special Issue Nutrition and Liver Disease)
View Full-Text   |   Download PDF [249 KB, uploaded 3 December 2014]   |  

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. It is a progressive disorder involving a spectrum of conditions that include pure steatosis without inflammation, nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. The key factor in the pathophysiology of NAFLD is insulin resistance that determines lipid accumulation in the hepatocytes, which may be followed by lipid peroxidation, production of reactive oxygen species and consequent inflammation. Recent studies suggest that the characteristics of the gut microbiota are altered in NAFLD, and also, that small intestinal bacterial overgrowth (SIBO) contributes to the pathogenesis of this condition. This review presents the chief findings from all the controlled studies that evaluated SIBO, gut permeability and endotoxemia in human NAFLD. We also discuss the possible mechanisms involving SIBO, lipid accumulation and development of NASH. The understanding of these mechanisms may allow the development of new targets for NASH treatment in the future. View Full-Text
Keywords: fatty liver; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; small intestinal bacterial overgrowth; gut microbiota; endotoxemia; bacterial translocation fatty liver; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; small intestinal bacterial overgrowth; gut microbiota; endotoxemia; bacterial translocation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ferolla, S.M.; Armiliato, G.N.A.; Couto, C.A.; Ferrari, T.C.A. The Role of Intestinal Bacteria Overgrowth in Obesity-Related Nonalcoholic Fatty Liver Disease. Nutrients 2014, 6, 5583-5599.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top