Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
Compounds | Contents (mg/100 g Extract) |
---|---|
Phenolic acid | |
Phloroglucinol | 924.58 |
Gallic acid | 85.28 |
Chlorogenic acid | 32.99 |
Caffeic acid | 37.18 |
p-Coumaric acid | 2.23 |
Trans-ferulic acid | 16.40 |
Total of phenolic acid | 1098.66 |
Flavonoids | |
(−)-Epigallocatechin | 1353.00 |
Epigallocatechin gallate | 20.64 |
Rutin hydrate | 391.08 |
Luteolin | 12.12 |
Total of flavonoids | 1776.84 |
2.2. Anti-Obesity Activity of Codonopsis lanceolata Root Extract
2.2.1. Study Design
2.2.2. Blood Chemistry
2.2.3. Specimen Collection
2.2.4. Determination of Fat Size of Adipose Tissue by Oil Red O Staining
2.2.5. Histology Preparation and Hematoxylin and Eosin Stain (H & E)
2.3. Statistical Analysis
3. Results
3.1. CLE Suppresses Body Weight Gain and Body Fat Accumulation in C57BL/6 Mice Fed HFD
3.2. CLE Ameliorate Impaired Lipid, Glucose, and Insulin Homeostasis in HFD-Induced Obese Mice
3.3. CLE Suppresses Hepatic Steatosis in HFD-Induced Obese Mice
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Lee, J.S.; Kim, K.-J.; Kim, Y.-H.; Kim, D.-B.; Shin, G.-H.; Cho, J.-H.; Kim, B.K.; Lee, B.-Y.; Lee, O.-H. Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice. Nutrients 2014, 6, 4663-4677. https://doi.org/10.3390/nu6114663
Lee JS, Kim K-J, Kim Y-H, Kim D-B, Shin G-H, Cho J-H, Kim BK, Lee B-Y, Lee O-H. Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice. Nutrients. 2014; 6(11):4663-4677. https://doi.org/10.3390/nu6114663
Chicago/Turabian StyleLee, Jong Seok, Kui-Jin Kim, Young-Hyun Kim, Dan-Bi Kim, Gi-Hae Shin, Ju-Hyun Cho, Bong Kyun Kim, Boo-Yong Lee, and Ok-Hwan Lee. 2014. "Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice" Nutrients 6, no. 11: 4663-4677. https://doi.org/10.3390/nu6114663