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Diurnal Triglyceridemia in Relation to Alcohol Intake in Men
Department of Internal Medicine, Center for Diabetes and Vascular Medicine, St Franciscus Gasthuis, P.O. Box 10900, Rotterdam 3004 BA, The Netherlands
IiSGM (Instituto de Investigación Sanitaria), HGU Gregorio Marañón (Hospital General Universitario Gregorio Marañón), Madrid 28007, Spain
Department of Statistics and Education, St Franciscus Gasthuis, P.O. Box 10900, Rotterdam 3004 BA, The Netherlands
Institute of Health Care Policy and Management, Erasmus University Rotterdam, Rotterdam 3004 BA, The Netherlands
Department of Physiology, School of Medicine, Universidad Complutense de Madrid, Madrid 28007, Spain
Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Madrid 28007, Spain
* Author to whom correspondence should be addressed.
Received: 12 September 2013; in revised form: 19 November 2013 / Accepted: 3 December 2013 / Published: 16 December 2013
Abstract: Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18–80 years) measured their own capillary triglyceride (cTG) concentrations daily on six fixed time-points before and after meals, and the total daily alcohol intake was recorded. The impact of daily alcohol intake (none; low, <10 g/day; moderate, 10–30 g/day; high, >30 g/day) on diurnal triglyceridemia was analyzed by the incremental area under the cTG curve (∆cTG-AUC) reflecting the mean of the six different time-points. Fasting cTG were similar between the alcohol groups, but a trend of increased cTG was observed in men with moderate and high alcohol intake after dinner and at bedtime (p for trend <0.001) which persisted after adjustment for age, smoking and body mass index. The ∆cTG-AUC was significantly lower in males with low alcohol intake (3.0 ± 1.9 mmol·h/L) (n = 27) compared to males with no (7.0 ± 1.8 mmol·h/L) (n = 34), moderate (6.5 ± 1.8 mmol·h/L) (n = 54) or high alcohol intake (7.2 ± 2.2 mmol·h/L) (n = 24), when adjusted for age, smoking and body mass index (adjusted p value < 0.05). In males, low alcohol intake was associated with decreased diurnal triglyceridemia, whereas moderate and high alcohol intake was associated with increased triglycerides after dinner and at bed time.
Keywords: ethanol; lipemia; postprandial; triglyceride
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Torres do Rego, A.; Klop, B.; Birnie, E.; Elte, J.W.F.; Ramos, V.C.; Walther, L.A.-S.; Cabezas, M.C. Diurnal Triglyceridemia in Relation to Alcohol Intake in Men. Nutrients 2013, 5, 5114-5126.
Torres do Rego A, Klop B, Birnie E, Elte JWF, Ramos VC, Walther LA-S, Cabezas MC. Diurnal Triglyceridemia in Relation to Alcohol Intake in Men. Nutrients. 2013; 5(12):5114-5126.
Torres do Rego, Ana; Klop, Boudewijn; Birnie, Erwin; Elte, Jan W.F.; Ramos, Victoria C.; Walther, Luis A.-S.; Cabezas, Manuel C. 2013. "Diurnal Triglyceridemia in Relation to Alcohol Intake in Men." Nutrients 5, no. 12: 5114-5126.