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Nutrients 2012, 4(7), 740-758; doi:10.3390/nu4070740
Review

Exercise and Amino Acid Anabolic Cell Signaling and the Regulation of Skeletal Muscle Mass

Received: 31 May 2012; in revised form: 29 June 2012 / Accepted: 2 July 2012 / Published: 10 July 2012
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Abstract: A series of complex intracellular networks influence the regulation of skeletal muscle protein turnover. In recent years, studies have examined how cellular regulators of muscle protein turnover modulate metabolic mechanisms contributing to the loss, gain, or conservation of skeletal muscle mass. Exercise and amino acids both stimulate anabolic signaling potentially through several intracellular pathways including the mammalian target of rapamycin complex 1 and the mitogen activated protein kinase cell signaling cascades. As novel molecular regulators of muscle integrity continue to be explored, a contemporary analysis of the literature is required to understand the metabolic mechanisms by which contractile forces and amino acids affect cellular process that contribute to long-term adaptations and preservation of muscle mass. This article reviews the literature related to how exercise and amino acid availability affect cellular regulators of skeletal muscle mass, especially highlighting recent investigations that have identified mechanisms by which contractile forces and amino acids modulate muscle health. Furthermore, this review will explore integrated exercise and nutrition strategies that promote the maintenance of muscle health by optimizing exercise, and amino acid-induced cell signaling in aging adults susceptible to muscle loss.
Keywords: mechanotransduction; leucine; hypertrophy; mTORC1; protein synthesis mechanotransduction; leucine; hypertrophy; mTORC1; protein synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pasiakos, S.M. Exercise and Amino Acid Anabolic Cell Signaling and the Regulation of Skeletal Muscle Mass. Nutrients 2012, 4, 740-758.

AMA Style

Pasiakos SM. Exercise and Amino Acid Anabolic Cell Signaling and the Regulation of Skeletal Muscle Mass. Nutrients. 2012; 4(7):740-758.

Chicago/Turabian Style

Pasiakos, Stefan M. 2012. "Exercise and Amino Acid Anabolic Cell Signaling and the Regulation of Skeletal Muscle Mass." Nutrients 4, no. 7: 740-758.



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