Next Article in Journal / Special Issue
Zinc and Regulation of Inflammatory Cytokines: Implications for Cardiometabolic Disease
Previous Article in Journal
Effect of Levan Supplement in Orange Juice on Weight, Gastrointestinal Symptoms and Metabolic Profile of Healthy Subjects: Results of an 8-Week Clinical Trial
Previous Article in Special Issue
Zinc Intake and Its Dietary Sources: Results of the 2007 Australian National Children’s Nutrition and Physical Activity Survey
Nutrients 2012, 4(7), 648-675; doi:10.3390/nu4070648

Zinc and Cancer: Implications for LIV-1 in Breast Cancer

1,*  and 2,*
1 Department of Family Medicine, Stony Brook University Hospital Medical Center, Stony Brook, New York, NY 11597, USA 2 Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06268, USA
* Authors to whom correspondence should be addressed.
Received: 3 May 2012 / Revised: 7 June 2012 / Accepted: 27 June 2012 / Published: 4 July 2012
(This article belongs to the Special Issue Zinc in Health and Disease)
View Full-Text   |   Download PDF [240 KB, uploaded 4 July 2012]


Zinc is a trace mineral which is vital for the functioning of numerous cellular processes, is critical for growth, and may play an important role in cancer etiology and outcome. The intracellular levels of this mineral are regulated through the coordinated expression of zinc transporters, which modulate both zinc influx as well as efflux. LIV-1 (ZIP6) was first described in 1988 as an estrogen regulated gene with later work suggesting a role for this transporter in cancer growth and metastasis. Despite evidence of its potential utility as a target gene for cancer prognosis and treatment, LIV-1 has received relatively little attention, with only three prior reviews being published on this topic. Herein, the physiological effects of zinc are reviewed in light of this mineral’s role in cancer growth with specific attention being given to LIV-1 and the potential importance of this transporter to breast cancer etiology.
Keywords: zinc; zinc transporters; cancer; LIV-1; ZIP6 zinc; zinc transporters; cancer; LIV-1; ZIP6
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Grattan, B.J.; Freake, H.C. Zinc and Cancer: Implications for LIV-1 in Breast Cancer. Nutrients 2012, 4, 648-675.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert