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Nutrients 2011, 3(5), 613-636; doi:10.3390/nu3050613

Lactobacillus Adhesion to Mucus

1 Department of Food Science and Human Nutrition, University of Illinois, 905 S. Goodwin Ave., Urbana, IL 61801, USA 2 Division of Nutritional Sciences, University of Illinois, 905 S. Goodwin Ave., Urbana, IL 61801, USA
* Author to whom correspondence should be addressed.
Received: 10 April 2011 / Revised: 5 May 2011 / Accepted: 11 May 2011 / Published: 20 May 2011
(This article belongs to the Special Issue Nutriceuticals)
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Mucus provides protective functions in the gastrointestinal tract and plays an important role in the adhesion of microorganisms to host surfaces. Mucin glycoproteins polymerize, forming a framework to which certain microbial populations can adhere, including probiotic Lactobacillus species. Numerous mechanisms for adhesion to mucus have been discovered in lactobacilli, including partially characterized mucus binding proteins. These mechanisms vary in importance with the in vitro models studied, which could significantly affect the perceived probiotic potential of the organisms. Understanding the nature of mucus-microbe interactions could be the key to elucidating the mechanisms of probiotic adhesion within the host.
Keywords: adhesion; binding; mucin; mucus; MUC2; lactobacillus; MucBP; probiotics adhesion; binding; mucin; mucus; MUC2; lactobacillus; MucBP; probiotics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Van Tassell, M.L.; Miller, M.J. Lactobacillus Adhesion to Mucus. Nutrients 2011, 3, 613-636.

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