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Lactobacillus Adhesion to Mucus
Department of Food Science and Human Nutrition, University of Illinois, 905 S. Goodwin Ave., Urbana, IL 61801, USA
Division of Nutritional Sciences, University of Illinois, 905 S. Goodwin Ave., Urbana, IL 61801, USA
* Author to whom correspondence should be addressed.
Received: 10 April 2011; in revised form: 5 May 2011 / Accepted: 11 May 2011 / Published: 20 May 2011
Abstract: Mucus provides protective functions in the gastrointestinal tract and plays an important role in the adhesion of microorganisms to host surfaces. Mucin glycoproteins polymerize, forming a framework to which certain microbial populations can adhere, including probiotic Lactobacillus species. Numerous mechanisms for adhesion to mucus have been discovered in lactobacilli, including partially characterized mucus binding proteins. These mechanisms vary in importance with the in vitro models studied, which could significantly affect the perceived probiotic potential of the organisms. Understanding the nature of mucus-microbe interactions could be the key to elucidating the mechanisms of probiotic adhesion within the host.
Keywords: adhesion; binding; mucin; mucus; MUC2; lactobacillus; MucBP; probiotics
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MDPI and ACS Style
Van Tassell, M.L.; Miller, M.J. Lactobacillus Adhesion to Mucus. Nutrients 2011, 3, 613-636.
Van Tassell ML, Miller MJ. Lactobacillus Adhesion to Mucus. Nutrients. 2011; 3(5):613-636.
Van Tassell, Maxwell L.; Miller, Michael J. 2011. "Lactobacillus Adhesion to Mucus." Nutrients 3, no. 5: 613-636.