Gut–Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Arthritis Induction
2.3. Bacterial Enumeration in Organs
2.4. Enumeration of Spleen CD11C+ DCs and CD4+ T Cells and Culture of Splenocytes in CIA Model
2.5. In Vivo and In Vitro Lpps Uptake
2.6. Statistical Analysis
3. Results
3.1. Protection against Arthritis Progression Depends on the Lpps Dose and Is Primarily Related to Ligilactobacillus murinus Intestinal Colonization
3.2. The Degree of Disease Progression Was Significantly Milder in Both Preventive and Therapeutic Lpps CAIA Groups
3.3. Higher IL-10 Splenocyte Response to LPS in CIA Lpps-Treated Mice Was Likely Related to CD11c+ DC Recruitment
3.4. Lpps Was Primarily Detected in Bone Marrow Plasmacytoid DCs at a Late Post-Gavage Stage
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Piva, F.; Gervois, P.; Karrout, Y.; Sané, F.; Romond, M.-B. Gut–Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development. Nutrients 2023, 15, 4861. https://doi.org/10.3390/nu15234861
Piva F, Gervois P, Karrout Y, Sané F, Romond M-B. Gut–Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development. Nutrients. 2023; 15(23):4861. https://doi.org/10.3390/nu15234861
Chicago/Turabian StylePiva, Frank, Philippe Gervois, Youness Karrout, Famara Sané, and Marie-Bénédicte Romond. 2023. "Gut–Joint Axis: Impact of Bifidobacterial Cell Wall Lipoproteins on Arthritis Development" Nutrients 15, no. 23: 4861. https://doi.org/10.3390/nu15234861