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Nutrients 2018, 10(9), 1257; https://doi.org/10.3390/nu10091257

Plasma Retinol Levels and High-Sensitivity C-Reactive Protein in Prepubertal Children

1
Lipid Laboratory, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain
2
Faculties of Pharmacy and Medicine, Universidad San Pablo-CEU, 28925 Madrid, Spain
3
Department of Pediatrics, IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain
4
Servicio de Bioquímica-Investigación, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 21 August 2018 / Revised: 3 September 2018 / Accepted: 5 September 2018 / Published: 7 September 2018
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Abstract

The relationship between C-reactive protein (CRP) levels and plasma antioxidants has been established in adults. However, the association has been rarely investigated in healthy children. Thus, we examined the cross-sectional association of high-sensitivity CRP (hs-CRP) levels with fat-soluble plasma antioxidant concentrations in a cohort of healthy prepubertal children. We determined hs-CRP levels in 543 healthy six–eight-year-old children using a high-sensitivity CRP enzyme-linked immuno sorbent assay (ELISA) kit. The plasma concentrations of lipids, apolipoproteins and lipid-soluble antioxidants (α-tocopherol, γ-tocopherol, lycopene, α-carotene, β-carotene and retinol) were determined using standardized methods. Pearson correlation analysis showed significant correlations between plasma hs-CRP and α-carotene and retinol concentrations. After adjusting by sex, body mass index (BMI) and lipid levels, only the association with retinol remains significant, with children in the highest hs-CRP tertile group (hs-CRP ≥ 0.60 mg/dL) showing significantly lower levels of retinol than those from the tertiles 1 and 2. A stepwise linear regression selected retinol, BMI, apo A-I and sex as predictors of hs-CRP levels, in a model explaining 19.2% of the variability of hs-CRP. In conclusion, in healthy prepubertal children, after adjusting by sex, BMI and lipid levels, hs-CRP concentrations were highly associated with plasma retinol, which is transported in blood bound to retinol-binding protein but were not associated with the lipoprotein-bound antioxidants. View Full-Text
Keywords: C-reactive protein; hs-CRP concentrations; fat-soluble plasma antioxidants; plasma retinol concentrations; prepubertal children C-reactive protein; hs-CRP concentrations; fat-soluble plasma antioxidants; plasma retinol concentrations; prepubertal children
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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de Dios, O.; Navarro, P.; Ortega-Senovilla, H.; Herrero, L.; Gavela-Pérez, T.; Soriano-Guillen, L.; Lasunción, M.A.; Garcés, C. Plasma Retinol Levels and High-Sensitivity C-Reactive Protein in Prepubertal Children. Nutrients 2018, 10, 1257.

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