Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds
AbstractObesity, a condition where excess body fat accumulates to the extent, causes a negative effect on health. Previously, we reported the extract of Dolichos lablab L. (DLL-Ex) inhibited high-fat diet (HFD)-induced increases in body weight and body fat mass and ameliorated increases in body weight. In the present work, we studyed the molecular mechanism for the inhibitory effect of DLL-Ex or Chikusetsusaponin IVa (CS-IVa), as isolated from Dolichos lablab L. (DLL) seeds extract, on adipocyte differentiation. We evaluated the effect of DLL-Ex, an anti-obesity agent, and CS-IVa, an active component of DLL-Ex, on 3T3-L1 cell differentiation via Oil red O assay and Q-PCR, along with their effects on CCAAT element binding protein alpha (C/EBPα), peroxisome proliferator-activated receptor gamma (PPARγ), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4) mRNA transcriptions. FAS and FABP4 protein expression levels after exposure to CS-IVa were also tested. The results showed that DLL-Ex and CS-IVa have potent inhibitory activity on adipocyte differentiation. Therefore, DLL and CS-IVa may be developed as a functional food material to treat obesity. View Full-Text
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Yin, J.; Seo, C.-S.; Hwang, I.H.; Lee, M.W.; Song, K.H. Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds. Nutrients 2018, 10, 1221.
Yin J, Seo C-S, Hwang IH, Lee MW, Song KH. Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds. Nutrients. 2018; 10(9):1221.Chicago/Turabian Style
Yin, Jun; Seo, Chang-Seob; Hwang, In H.; Lee, Min W.; Song, Kwang H. 2018. "Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds." Nutrients 10, no. 9: 1221.
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