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Nutrients 2018, 10(9), 1199; https://doi.org/10.3390/nu10091199

Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance

1
Department of Pathophysiology, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
2
Second Surgical Clinic, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy Cluj-Napoca 400012, Romania
3
Department of Biochemistry, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
4
Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca 400012, Romania
5
Department of Exact Sciences, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca 400012, Romania
*
Author to whom correspondence should be addressed.
Received: 18 July 2018 / Revised: 23 August 2018 / Accepted: 29 August 2018 / Published: 1 September 2018
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Abstract

Metabolically heathy obesity is characterised by the presence of obesity in the absence of metabolic disturbances. The aim of our study was to analyse pro-inflammatory, nitro-oxidative stress, and insulin-resistance (IR) markers in metabolically healthy morbidly obese (MHMO) with respect to metabolically unhealthy morbidly obese (MUHMO) with metabolic syndrome (MS) and to identify the potential predictors of MS in the MHMO group. Two groups of MHMO and MUHMO with MS were analysed. We evaluated serum high sensitivity C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), chemerin, nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), fasting blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR.) MHMO have similar hsCRP and TNF-α values as the MUHMO with MS, while chemerin was significantly lower in MHMO. NOx was higher in MUHMO with MS patients, while no difference regarding TOS and TAR was found between the two groups. HOMA-IR and insulin values were lower in MHMO as compared to the MUHMO with MS group. Insulin, HOMA-IR, and chemerin were identified predictors of MS in MHMO. In conclusion, MHMO and MUHMO display similarities and differences in terms of chronic inflammation, nitro-oxidative stress, and IR. Markers of IR and chemerin are possible predictors of MS in MHMO. View Full-Text
Keywords: metabolically healthy morbidly obese; metabolically unhealthy morbidly obese; metabolic syndrome; chronic inflammation; nitro-oxidative stress; insulin-resistance metabolically healthy morbidly obese; metabolically unhealthy morbidly obese; metabolic syndrome; chronic inflammation; nitro-oxidative stress; insulin-resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Cӑtoi, A.F.; Pârvu, A.E.; Andreicuț, A.D.; Mironiuc, A.; Crӑciun, A.; Cӑtoi, C.; Pop, I.D. Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance. Nutrients 2018, 10, 1199.

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