Next Article in Journal
Socio-Ecological Barriers to Dry Grain Pulse Consumption among Low-Income Women: A Mixed Methods Approach
Previous Article in Journal
An Audit of Australian Bread with a Focus on Loaf Breads and Whole Grain
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Nutrients 2018, 10(8), 1107; https://doi.org/10.3390/nu10081107

Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats

1
Department of Physiology, School of Medicine & Biosanitary Research Murcian Institute (IMIB), University of Murcia, 30120 Murcia, Spain
2
Department of Pathological Anatomy, School of Medicine, IBIMER (CIBM) & Ibs.GRANADA, University of Granada, 18016 Granada, Spain
3
Institute of Aging & R & D, Nutrafur SA-FRUTAROM Group, 30820 Alcantarilla, Spain
*
Author to whom correspondence should be addressed.
Received: 20 July 2018 / Revised: 14 August 2018 / Accepted: 15 August 2018 / Published: 16 August 2018
Full-Text   |   PDF [2385 KB, uploaded 20 August 2018]   |  

Abstract

Many studies have shown that flavonoids are effective as antihypertensive drugs in arterial hypertension. In the present work, we have analyzed the effects of some flavonoid extracts in the spontaneous hypertensive rat model (SHR). An important feature of this study is that we have used a low dose, far from those that are usually applied in human therapy or experimental animals, a dose that responded to the criterion of a potential future commercial use in human subjects. Treatments were carried out for 6 and 12 weeks in two groups of SHR rats, which received apigenin, lemon extract, grapefruit + bitter orange (GBO) extracts, and cocoa extract. Captopril was used as a positive control in the SHR group treated for 6 weeks (SHR6) and Diosmin was used as the industry reference in the SHR group treated for 12 weeks (SHR12). Captopril and GBO extracts lowered the high arterial pressure of the SHR6 animals, but none of the extracts were effective in the SHR12 group. Apigenin, lemon extract (LE), GBO, and captopril also improved aortic vascular relaxation and increased plasma and urinary excretion of nitrites, but only in the SHR6 group. Kidney and urinary thiobarbituric acid reactive substances (TBARS) were also significantly reduced by GBO in the SHR6 rats. Apigenin also improved vascular relaxation in the SHR12 group and all the flavonoids studied reduced urinary thiobarbituric acid reactive substances (TBARS) excretion and proteinuria. Vascular abnormalities, such as lumen/wall ratio in heart arteries and thoracic aorta, were moderately improved by these treatments in the SHR6 group. In conclusion, the flavonoid-rich extracts included in this study, especially apigenin, LE and GBO improved vascular vasodilatory function of young adult SHRs but only the GBO-treated rats benefited from a reduction in blood pressure. These extracts may be used as functional food ingredients with a moderate therapeutic benefit, especially in the early phases of arterial hypertension. View Full-Text
Keywords: flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Paredes, M.D.; Romecín, P.; Atucha, N.M.; O’Valle, F.; Castillo, J.; Ortiz, M.C.; García-Estañ, J. Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats. Nutrients 2018, 10, 1107.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top