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Approaching Resonant Absorption of Environmental Xenobiotics Harmonic Oscillation by Linear Structures
University of Craiova, Faculty of Electrical Engineering, Craiova 200440, Romania
Faculty of Engineering and Applied Science, University of Ontario Institute of Technology, Oshawa, ON L1H 7K4, Canada
Technical University of Sofia, Industrial Engineering Department, Sofia, Bulgaria & Military Institutions of University Education (ASEI), Hellenic Naval Academy, Piraeus 18539, Greece
University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania
* Author to whom correspondence should be addressed.
Received: 1 February 2012; in revised form: 20 March 2012 / Accepted: 21 March 2012 / Published: 30 March 2012
Abstract: Over the last several decades, it has become increasingly accepted that the term xenobiotic relates to environmental impact, since environmental xenobiotics are understood to be substances foreign to a biological system, which did not exist in nature before their synthesis by humans. In this context, xenobiotics are persistent pollutants such as dioxins and polychlorinated biphenyls, as well as plastics and pesticides. Dangerous and unstable situations can result from the presence of environmental xenobiotics since their harmful effects on humans and ecosystems are often unpredictable. For instance, the immune system is extremely vulnerable and sensitive to modulation by environmental xenobitics. Various experimental assays could be performed to ascertain the immunotoxic potential of environmental xenobiotics, taking into account genetic factors, the route of xenobiotic penetration, and the amount and duration of exposure, as well as the wave shape of the xenobiotic. In this paper, we propose an approach for the analysis of xenobiotic metabolism using mathematical models and corresponding methods. This study focuses on a pattern depicting mathematically modeled processes of resonant absorption of a xenobiotic harmonic oscillation by an organism modulated as an absorbing oscillator structure. We represent the xenobiotic concentration degree through a spatial concentration vector, and we model and simulate the oscillating regime of environmental xenobiotic absorption. It is anticipated that the results could be used to facilitate the assessment of the processes of environmental xenobiotic absorption, distribution, biotransformation and removal within the framework of compartmental analysis, by establishing appropriate mathematical models and simulations.
Keywords: environment; health; environmental xenobiotics; absorption; harmonic oscillation; immunotoxicology
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Bulucea, C.A.; Rosen, M.A.; Mastorakis, N.E.; Bulucea, C.A.; Brindusa, C.C. Approaching Resonant Absorption of Environmental Xenobiotics Harmonic Oscillation by Linear Structures. Sustainability 2012, 4, 561-573.
Bulucea CA, Rosen MA, Mastorakis NE, Bulucea CA, Brindusa CC. Approaching Resonant Absorption of Environmental Xenobiotics Harmonic Oscillation by Linear Structures. Sustainability. 2012; 4(4):561-573.
Bulucea, Cornelia A.; Rosen, Marc A.; Mastorakis, Nikos E.; Bulucea, Carmen A.; Brindusa, Corina C. 2012. "Approaching Resonant Absorption of Environmental Xenobiotics Harmonic Oscillation by Linear Structures." Sustainability 4, no. 4: 561-573.