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Pharmaceutics 2017, 9(4), 41; https://doi.org/10.3390/pharmaceutics9040041

Predicting Oral Drug Absorption: Mini Review on Physiologically-Based Pharmacokinetic Models

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
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Received: 16 August 2017 / Revised: 20 September 2017 / Accepted: 22 September 2017 / Published: 26 September 2017
(This article belongs to the Special Issue Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape)
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Abstract

Most marketed drugs are administered orally, despite the complex process of oral absorption that is difficult to predict. Oral bioavailability is dependent on the interplay between many processes that are dependent on both compound and physiological properties. Because of this complexity, computational oral physiologically-based pharmacokinetic (PBPK) models have emerged as a tool to integrate these factors in an attempt to mechanistically capture the process of oral absorption. These models use inputs from in vitro assays to predict the pharmacokinetic behavior of drugs in the human body. The most common oral PBPK models are compartmental approaches, in which the gastrointestinal tract is characterized as a series of compartments through which the drug transits. The focus of this review is on the development of oral absorption PBPK models, followed by a brief discussion of the major applications of oral PBPK models in the pharmaceutical industry. View Full-Text
Keywords: oral absorption; physiologically-based pharmacokinetic modeling; food-effect; pH effect; formulation simulation oral absorption; physiologically-based pharmacokinetic modeling; food-effect; pH effect; formulation simulation
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Lin, L.; Wong, H. Predicting Oral Drug Absorption: Mini Review on Physiologically-Based Pharmacokinetic Models. Pharmaceutics 2017, 9, 41.

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