Next Article in Journal
Quality Attributes and In Vitro Bioequivalence of Different Brands of Amoxicillin Trihydrate Tablets
Previous Article in Journal
Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessArticle
Pharmaceutics 2017, 9(2), 17; doi:10.3390/pharmaceutics9020017

Optimizing Prednisolone Loading into Distiller’s Dried Grain Kafirin Microparticles, and In vitro Release for Oral Delivery

1
School of Pharmacy, University of Queensland, 4072 Brisbane, Australia
2
School of Clinical Sciences, Queensland University of Technology, 4000 Brisbane, Australia
3
Nutrition, Dietetics and Food Technology, School of Public Health, Faculty of Health Sciences, Curtin University, 6845 Perth, Australia
4
Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, University of Queensland, 4072 Brisbane, Australia
5
ARC Centre of Excellence in Plant Cell Walls, University of Queensland, 4072 Brisbane, Australia
6
Innovative Food Technologies, Department of Agriculture and Fisheries, 4108 Brisbane, Australia
7
Centre for Food Innovation, University of Tasmania, 7001 Hobart, Australia
8
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, 4072 Brisbane, Australia
9
School of Chemical Engineering, University of Queensland, 4072 Brisbane, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Ruggero Bettini
Received: 10 March 2017 / Revised: 20 April 2017 / Accepted: 2 May 2017 / Published: 19 May 2017
View Full-Text   |   Download PDF [2668 KB, uploaded 21 May 2017]   |  

Abstract

Kafirin microparticles have potential as colon-targeted delivery systems because of their ability to protect encapsulated material from digestive processes of the upper gastrointestinal tract (GIT). The aim was to optimize prednisolone loading into kafirin microparticles, and investigate their potential as an oral delivery system. Response surface methodology (RSM) was used to predict the optimal formulation of prednisolone loaded microparticles. Prednisolone release from the microparticles was measured in simulated conditions of the GIT. The RSM models were inadequate for predicting the relationship between starting quantities of kafirin and prednisolone, and prednisolone loading into microparticles. Compared to prednisolone released in the simulated gastric and small intestinal conditions, no additional drug release was observed in simulated colonic conditions. Hence, more insight into factors affecting drug loading into kafirin microparticles is required to improve the robustness of the RSM model. This present method of formulating prednisolone-loaded kafirin microparticles is unlikely to offer clinical benefits over commercially available dosage forms. Nevertheless, the overall amount of prednisolone released from the kafirin microparticles in conditions simulating the human GIT demonstrates their ability to prevent the release of entrapped core material. Further work developing the formulation methods may result in a delivery system that targets the lower GIT. View Full-Text
Keywords: kafirin; distiller’s dried grains with solubles; microparticles; response surface methodology; simulated gastrointestinal conditions; colonic delivery kafirin; distiller’s dried grains with solubles; microparticles; response surface methodology; simulated gastrointestinal conditions; colonic delivery
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lau, E.T.L.; Johnson, S.K.; Williams, B.A.; Mikkelsen, D.; McCourt, E.; Stanley, R.A.; Mereddy, R.; Halley, P.J.; Steadman, K.J. Optimizing Prednisolone Loading into Distiller’s Dried Grain Kafirin Microparticles, and In vitro Release for Oral Delivery. Pharmaceutics 2017, 9, 17.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top