Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation
AbstractHigh-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA). A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by using a diamond anvil cell. A comparison of the crystal structures shows that the efficient packing of molecules in Form II was enabled by the structural flexibility of MA molecules. Compression studies performed on a single crystal of Form I resulted in a 14% decrease of unit cell volume up to 2.5 GPa. No phase transition was observed up to this pressure. A reconstructive phase transition is required to induce conformational changes in the structure, which was confirmed by the results of crystallisation at high pressure. View Full-Text
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Abbas, N.; Oswald, I.D.H.; Pulham, C.R. Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation. Pharmaceutics 2017, 9, 16.
Abbas N, Oswald IDH, Pulham CR. Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation. Pharmaceutics. 2017; 9(2):16.Chicago/Turabian Style
Abbas, Nasir; Oswald, Iain D.H.; Pulham, Colin R. 2017. "Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation." Pharmaceutics 9, no. 2: 16.
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