Next Article in Journal
Current Trends in Development of Liposomes for Targeting Bacterial Biofilms
Next Article in Special Issue
TPGS-Stabilized Curcumin Nanoparticles Exhibit Superior Effect on Carrageenan-Induced Inflammation in Wistar Rat
Previous Article in Journal / Special Issue
Nanomilling of Drugs for Bioavailability Enhancement: A Holistic Formulation-Process Perspective
Article Menu

Export Article

Open AccessReview
Pharmaceutics 2016, 8(2), 16; doi:10.3390/pharmaceutics8020016

Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability

Division of Pharmaceutical Chemistry and Technology, P.O. Box 56 (Viikinkaari 5 E), University of Helsinki, 00014 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Arvind K. Bansal
Received: 15 March 2016 / Revised: 12 May 2016 / Accepted: 16 May 2016 / Published: 20 May 2016
(This article belongs to the Special Issue Nanocrystals)
View Full-Text   |   Download PDF [2673 KB, uploaded 20 May 2016]   |  

Abstract

Drug nanocrystals are a versatile option for drug delivery purposes, and while the number of poorly soluble drug materials is all the time increasing, more research in this area is performed. Drug nanocrystals have a simple structure—a solid drug core is surrounded by a layer of stabilizing agent. However, despite the considerably simple structure, the selection of an appropriate stabilizer for a certain drug can be challenging. Mostly, the stabilizer selection is based purely on the requirement of physical stability, e.g., maintaining the nanosized particle size as long as possible after the formation of drug nanocrystals. However, it is also worth taking into account that stabilizer can affect the bioavailability in the final formulation via interactions with cells and cell layers. In addition, formation of nanocrystals is only one process step, and for the final formulation, more excipients are often added to the composition. The role of the stabilizers in the final formulation can be more than only stabilizing the nanocrystal particle size. A good example is the stabilizer’s role as cryoprotectant during freeze drying. In this review, the stabilizing effect, role of stabilizers in final nanocrystalline formulations, challenges in reaching in vitro–in vivo correlation with nanocrystalline products, and stabilizers’ effect on higher bioavailability are discussed. View Full-Text
Keywords: bioavailability; drug nanocrystals; polymers; stabilizer; surfactants bioavailability; drug nanocrystals; polymers; stabilizer; surfactants
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tuomela, A.; Hirvonen, J.; Peltonen, L. Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability. Pharmaceutics 2016, 8, 16.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top