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Pharmaceutics 2015, 7(4), 438-470; doi:10.3390/pharmaceutics7040438

Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum

1
School of Pharmacy, 97 Lisburn Road, Queens University Belfast, Belfast BT9 7BL, Northern Ireland, UK
2
Faculty of Pharmacy, Zarqa University, Zarqa 132222, Jordan
*
Author to whom correspondence should be addressed.
Academic Editor: Diganta B. Das
Received: 19 August 2015 / Revised: 29 September 2015 / Accepted: 13 October 2015 / Published: 22 October 2015
(This article belongs to the Special Issue Microneedle Patches: Developing Strategies for Delivery)
View Full-Text   |   Download PDF [3307 KB, uploaded 22 October 2015]   |  

Abstract

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies. View Full-Text
Keywords: transdermal; drug delivery; velocity based device; ultrasound; thermal ablation; mechanical and electrical approaches; microneedle transdermal; drug delivery; velocity based device; ultrasound; thermal ablation; mechanical and electrical approaches; microneedle
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Alkilani, A.Z.; McCrudden, M.T.C.; Donnelly, R.F. Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum. Pharmaceutics 2015, 7, 438-470.

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