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Pharmaceutics 2015, 7(3), 213-223; doi:10.3390/pharmaceutics7030213

Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan
Author to whom correspondence should be addressed.
Academic Editor: Keiji Itaka
Received: 26 June 2015 / Revised: 13 August 2015 / Accepted: 18 August 2015 / Published: 21 August 2015
(This article belongs to the Special Issue New Paradigm of Gene Therapy)
View Full-Text   |   Download PDF [1572 KB, uploaded 21 August 2015]   |  


Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydrodynamics-based gene delivery in large animals directly supports the clinical applicability of this technique. This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application. View Full-Text
Keywords: gene therapy; hydrodynamics-based gene delivery; DNA; clinical application gene therapy; hydrodynamics-based gene delivery; DNA; clinical application

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kamimura, K.; Yokoo, T.; Abe, H.; Kobayashi, Y.; Ogawa, K.; Shinagawa, Y.; Inoue, R.; Terai, S. Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions. Pharmaceutics 2015, 7, 213-223.

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