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Pharmaceutics 2014, 6(3), 530-542; doi:10.3390/pharmaceutics6030530

Characterization of Commercially Available Vaginal Lubricants: A Safety Perspective

1
CICS-UBI: Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal
2
Labfit–Health Products Research and Development (HPRD), Lda, 6200-506 Covilhã, Portugal
3
Child and Women Health Department, Centro Hospitalar Cova da Beira, 6200-251 Covilhã, Portugal
4
INEB–Instituto de Engenharia Biomédica, University of Porto, 4150-180 Porto, Portugal
5
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, 4585-116 Gandra PRD, Portugal
6
Pharmacy Department, Centro Hospitalar Cova da Beira, 6200-251 Covilhã, Portugal
*
Authors to whom correspondence should be addressed.
Received: 21 July 2014 / Revised: 5 September 2014 / Accepted: 9 September 2014 / Published: 22 September 2014
(This article belongs to the Special Issue Dosage Forms and Delivery Systems for Vaginal Therapy)
View Full-Text   |   Download PDF [1126 KB, uploaded 22 September 2014]   |  

Abstract

Vaginal lubricants are widely used by women to help solve intercourse difficulties or as enhancers, but recent reports raise questions about their safety. Twelve commercially available gel products were tested for pH value, pH buffering capacity, osmolality and cytotoxicity relevant to vaginal delivery. Obtained data were analyzed in light of the recent Advisory Note by the World Health Organization (WHO) for personal lubricants to be concomitantly used with condoms. Results showed that most products do not comply with pH and osmolality recommended standards, thus posing a potential hazard. Four products presented values of osmolality around three-times higher than the maximum acceptable limit of 1200 mOsm/kg. In vitro cell testing further identified substantial cytotoxicity even at 1:100 dilutions for three products, contrasting with no significant effect of up to at least a 1:5 dilution of a Universal Placebo gel. However, no direct correlation between these last results and pH or osmolality was found, thus suggesting that the individual toxicity of specific formulation components plays an important role in the outcome of a particular product. Although further assessment is required, these results highlight potential safety issues related to the formulation of commercially available vaginal lubricants. View Full-Text
Keywords: vaginal drug delivery; microbicides; buffer capacity; osmolality; cytotoxicity vaginal drug delivery; microbicides; buffer capacity; osmolality; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Cunha, A.R.; Machado, R.M.; Palmeira-de-Oliveira, A.; Martinez-de-Oliveira, J.; das Neves, J.; Palmeira-de-Oliveira, R. Characterization of Commercially Available Vaginal Lubricants: A Safety Perspective. Pharmaceutics 2014, 6, 530-542.

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