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Pharmaceutics 2014, 6(2), 298-332; doi:10.3390/pharmaceutics6020298

Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, P.O. Box 98, Beijing 100029, China
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Received: 11 April 2014 / Revised: 15 May 2014 / Accepted: 20 May 2014 / Published: 17 June 2014
(This article belongs to the Special Issue Layered Double Hydroxide Used in Drug Delivery)

Abstract

Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize intercalated structures have a significant influence on the development of new applications of these materials. We also show how modification and/or functionalization can lead to new biotechnological and biomedical applications. This review highlights the most recent progresses in research on LDH-based controlled drug delivery systems, focusing mainly on: (i) DDS with cardiovascular drugs as guests; (ii) DDS with anti-inflammatory drugs as guests; and (iii) DDS with anti-cancer drugs as guests. Finally, future prospects for LDH-based drug carriers are also discussed.
Keywords: layered double hydroxides; drug delivery system; controlled release; intercalation assembly; cardiovascular drug; anti-inflammatory drug; anti-cancer drug layered double hydroxides; drug delivery system; controlled release; intercalation assembly; cardiovascular drug; anti-inflammatory drug; anti-cancer drug
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bi, X.; Zhang, H.; Dou, L. Layered Double Hydroxide-Based Nanocarriers for Drug Delivery. Pharmaceutics 2014, 6, 298-332.

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