Pharmaceutics 2014, 6(2), 298-332; doi:10.3390/pharmaceutics6020298

Layered Double Hydroxide-Based Nanocarriers for Drug Delivery

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Received: 11 April 2014; in revised form: 15 May 2014 / Accepted: 20 May 2014 / Published: 17 June 2014
(This article belongs to the Special Issue Layered Double Hydroxide Used in Drug Delivery)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize intercalated structures have a significant influence on the development of new applications of these materials. We also show how modification and/or functionalization can lead to new biotechnological and biomedical applications. This review highlights the most recent progresses in research on LDH-based controlled drug delivery systems, focusing mainly on: (i) DDS with cardiovascular drugs as guests; (ii) DDS with anti-inflammatory drugs as guests; and (iii) DDS with anti-cancer drugs as guests. Finally, future prospects for LDH-based drug carriers are also discussed.
Keywords: layered double hydroxides; drug delivery system; controlled release; intercalation assembly; cardiovascular drug; anti-inflammatory drug; anti-cancer drug
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MDPI and ACS Style

Bi, X.; Zhang, H.; Dou, L. Layered Double Hydroxide-Based Nanocarriers for Drug Delivery. Pharmaceutics 2014, 6, 298-332.

AMA Style

Bi X, Zhang H, Dou L. Layered Double Hydroxide-Based Nanocarriers for Drug Delivery. Pharmaceutics. 2014; 6(2):298-332.

Chicago/Turabian Style

Bi, Xue; Zhang, Hui; Dou, Liguang. 2014. "Layered Double Hydroxide-Based Nanocarriers for Drug Delivery." Pharmaceutics 6, no. 2: 298-332.

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