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• Pickrell, A
• Harris, A
• Ngo, S
• Amireskandari, A
• Stewart, E
• Siesky, B
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• Pickrell, A
• Harris, A
• Ngo, S
• Amireskandari, A
• Stewart, E
• Siesky, B
• [+] on PubMed
• Pickrell, A
• Harris, A
• Ngo, S
• Amireskandari, A
• Stewart, E
• Siesky, B

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Pharmaceutics 2012, 4(1), 230-242; doi:10.3390/pharmaceutics4010230

Review

Delivery of Intraocular Triamcinolone Acetonide in the Treatment of Macular Edema

Aaron Pickrell, Alon Harris* , Sandra Ngo, Annahita Amireskandari, Erin Stewart and Brent Siesky

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, 1160 W. Michigan Street, Room 205Q, Indianapolis, IN 46202, USA

* Author to whom correspondence should be addressed.

Received: 7 February 2012; in revised form: 28 February 2012 / Accepted: 9 March 2012 / Published: 15 March 2012

(This article belongs to the Special Issue Ocular Drug Delivery)

Download PDF Full-Text [227 KB, uploaded 16 March 2012 08:18 CET]

Abstract: Macular edema (ME) is one of the eventual outcomes of various intraocular and systemic pathologies. The pathogenesis for ME is not yet entirely understood; however, some of the common risk factors for its development have been identified. While this investigation will not discuss the numerous etiologies of ME in detail, it appraises the two most widely studied delivery modalities of intraocular corticosteroids in the treatment of ME—intravitreal injection (IVI) and sub-Tenon’s infusion (STI). A thorough review of the medical literature was conducted to identify the efficacy and safety of IVI and STI, specifically for the administration of triamcinolone acetonide (TA), in the setting of ME in an attempt to elucidate a preferred steroid delivery modality for treatment of ME.

Keywords: macular edema; intravitreal injection; sub-Tenon’s injection; corticosteroids; triamcinolone

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